Abstract
The role of the thymus on immunity of rats againstTrypanosoma cruzi infection was investigated in vivo. The athymic (nu/nu) rats were shown to be significantly more susceptible to the acute phase of the infection than the control nu/+ rats, as measured by increased parasitemia and mortality. Specific anti-T. cruzi antibodies, complement, IgM and IgG2a serum levels were determined. The results would indicate the essential role of antibodies in immunity to acute Chagas' disease through T-dependent immune response.
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References
Abrahamsohn IA, Da Silva D (1977) Antibody-dependent cell-mediated cytotoxicity againstTrypanosoma cruzi. Parasitology 75: 317–323
Afchain D, Le Ray D, Fruit J, Capron A (1979) Antigenic make-up ofTrypanosoma cruzi culture forms: identification of a specific component. J Parasitol 65: 507–514
Bazin H, Beckers A, Querinjean P (1974) Three classes and four subclasses of rat immunoglobulins: IgM, IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c. Eur J Immunol 4: 44
Bazin H, Platteau B, Beckers A, Pauwels R (1978) Differential effect of neonatal injections of anti-μ or anti-ε antibodies on the synthesis of IgM, IgD, IgE, IgA, IgG1, IgG2a, IgG2b and IgG2c immunoglobulin classes. J Immunol 121: 2083–2087
Bazin H, Platteau B, Pauwels R, Capron A (1980) Immunoglobulin production in nude rats with special attention to the IgE isotype. Ann Immunol (Paris) 131C: 31–37
Brener Z (1962) Observaçôes sôbre a immunidade a superinfecçoes em camundongos experimentalmente inoculados comTrypanosoma cruzi e sumetidos a tratamento. Rev Inst Med Trop Sao Paulo 4: 119–123
Dalmasso AP, Jarvinen JA (1980) Experimental Chagas', disease in complement-deficient mice and guinea pigs. Infect Immun 28: 434–440
Kierszenbaum F, Howard JG (1976) Mechanisms of resistance against experimentalTrypanosoma cruzi infection: the importance of antibodies and antibody-forming capacity in the Biozzi high and low responder mice. J Immunol 116: 1208–1211
Kierszenbaum F, Pienkowski MN (1979) Thymus-dependent control of host defense mechanisms againstTrypanosoma cruzi infection. Infect Immun 24: 117–120
Krettli AU, Brener Z (1976) Protective effects of specific antibodies inTrypanosoma cruzi infections. J Immunol 116: 755–760
Lachmann PJ, Hobart MJ (1978) Complement technology. In: Weir DM (ed) Handbook of Experimental Immunology, 3rd edn. Blackwell Scientific Publications, Oxford, pp 5A1–5A23
Madeira ED, Andrade AFB, Bunn-Moreno MM, Barcinski M (1979) Antibody-dependent cellular cytotoxicity ofTrypanosoma cruzi: characterization of the effector cell from normal human blood. Infect Immun 25: 34–38
McHardy N (1977) Passive immunization of mice againstTrypanosoma cruzi using convalescent mouse serum. Tropenmed Parasitol 28: 195–201
Riera NE, Malbron A, Ritacco V, Cossio PM, Arana RM, de Biaco MM (1980) El sistema complemento en la enfermedad de Chagas cronica. Medicina (Buenos Aires) 40: 125–132
Rivera-Vanderpas MT, Rodriguez AM, Afchain D, Bazin H, Capron A (1983)Trypanosoma cruzi: variation in susceptibility of inbred strains of rats. Acta Tropica (in press)
Roberson EL, Chapman WL, Hanson WL (1973a) The effects of total body X-irradiation onTrypanosoma cruzi infection (Chagas' disease) in mice and rats. Z Parasitenkd 41: 83–94
Roberson EL, Hanson WL, Chapman WL (1973b)Trypanosoma cruzi: effects of anti-thymocyte serum in mice and neonatal thymectomy in rats. Exp Parasitol 34: 168–173
Rodriguez AM, Santoro F, Afchain D, Bazin H, Capron A (1980)Trypanosoma cruzi infection in B-cell-deficient rats. Infect Immun 31: 524–529
Sanderson CJ, Clark IA, Taylor GA (1975) Different effector cell-types in antibody-dependent cell-mediated cytotoxicity. Nature 253: 376–377
Santoro F, Bernal J, Capron A (1979) Complement activation by parasites. A review. Acta Trop (Basel) 36: 5–17
Scott MT (1981) The nature of immunity againstTrypanosoma cruzi in mice recovered from acute infection. Parasit Immun 3: 209–218
Trischmann TM (1980)Trypanosoma cruzi: Ability of T-cell-enriched and-depleted lymphocyte populations to passively protect mice. Exp Parasit 49: 225–232
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Rodriguez, A.M., Afchain, D., Santoro, F. et al. Parasitological and immunological aspects ofTrypanosoma cruzi infection in nude rats. Z. Parasitenkd. 69, 141–147 (1983). https://doi.org/10.1007/BF00926950
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DOI: https://doi.org/10.1007/BF00926950