Zeitschrift für Parasitenkunde

, Volume 68, Issue 1, pp 39–45 | Cite as

Cellular changes in bone marrow of malaria-infected mice

III. Chemotaxis of Granulocytes
  • S. Frankenburg
  • M. V. Londner
  • C. L. Greenblatt
Original Investigations


The number of bone marrow cells and their chemotactic activity was studied during malaria infection. Two days after infection of Balb/c mice withPlasmodium berghei, an increase in granulocyte number was observed in the blood. A modified Boyden chamber chemotaxis assay was employed to investigate the mechanism of granulocyte accumulation in the blood. Bone marrow cells from normal mice, from mice during a primary lethal infection and from immune mice after challenge were compared. The complement factor C5a showed chemotactic activity for bone marrow cells; a significant decrease of chemotaxis was only observed after 6 days of primary infection. Extracts of spleen, liver and infected erythrocytes lacked chemotactic activity, or caused inhibition of cell migration. Serum from mice with a 2-day primary infection contained chemotactic activity. The active component was heat labile, protease sensitive and had an estimated molecular weight of 250,000.


Malaria Bone Marrow Cell Primary Infection Malaria Infection Immune Mouse 
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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • S. Frankenburg
    • 1
    • 2
  • M. V. Londner
    • 1
    • 2
  • C. L. Greenblatt
    • 1
  1. 1.Department of ProtozoologyThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael
  2. 2.S.F. Kuvin Centre for the Study of Infectious and Tropical DiseasesThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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