Skip to main content
Log in

Resistance toTrypanosoma cruzi infection in relation to the timing of IgG humoral response

  • Original Investigations
  • Published:
Zeitschrift für Parasitenkunde Aims and scope Submit manuscript

Abstract

The Biozzi “high” (BH) and “low” (BL) responder mice (Selection III) differeed in their susceptibility toTrypanosoma cruzi. The BH strain responded quickly to the infection, similar to the reaction of (CBA×C57B1/10)F1 mice but in contrast to the susceptible BL strain. We suggest that the IgG response mounted by the host during the prepatent period of the infection is crucial to the outcome of the infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  • Barretto MP (1968) Reservatórios. In: Romeu Cançado J (ed) Doença de Chagas. Imprensa Oficial do Estado de Minas Gerais, Belo Horizonte pp 163–188

    Google Scholar 

  • Biozzi G, Stiffel C, Mouton D, Bouthillier Y, Decreusefond C (1971) Genetic regulation of the function of antibody producing cells. In: Amos B (ed) Progress in Immunology. First International Congress of Immunology. Academic Press, New York pp 529–545

    Google Scholar 

  • Brener Z (1968) Terapêutica Experimental. In: Romeu Cançado J (ed) Doença de Chagas. Imprensa Oficial do Estado de Minas Gerais, Belo Horizonte pp 501–516

    Google Scholar 

  • Brener Z, Krettly AU, Alcantara F A (1978) Role of the spleen in Chagas' disease. In: WHO Tropical Diseases Research Series no 1 The Role of the Spleen in the Immunology of Parasitic Diseases. Schwabe and Co. A.G., Basel, pp 121–135

    Google Scholar 

  • Burgess DE, Hanson WL (1980)Trypanosoma cruzi: The T-cell dependence of the primary immune response and the effects of depletion of T cells and Ig-bearing cells on immunological memory. Cell Immunol 52:176–186

    Google Scholar 

  • Camargo ME (1966) Fluorescent antibody test for the serodiagnosis of American Trypanosomiasis. Technical modification employing preserved culture forms ofT. cruzi in a slide test. Rev Inst Med trop São Paulo 8:227–234

    Google Scholar 

  • Chagas C (1909) Nova tripanosomiase humana. Estudos sobre a morfologia e o ciclo evolutivo doSchizotrypanum cruzi n. gen. n. sp. agente etiológico de nova entidade mórbida no homem. Mem Inst Oswaldo Cruz 1:159–218

    Google Scholar 

  • Corsini AC, Costa MG (1981) Immunosuppression in mice infected withTrypanosoma cruzi (Chagas 1909) — Evidence of polyclonal B cell activation in experimental infections mimicked by an extract prepared from circulating trypomastigotes. Rev Inst Med trop São Paulo 23:114–121

    Google Scholar 

  • Corsini AC, Costa MG, Oliveira OLP, Camargo JJB, Stelini A (1980b) Susceptibility of inbred mice toT. cruzi strain Y. Rev Inst Med trop São Paulo 22:192–196

    Google Scholar 

  • Corsini AC, Oliveira OLP, Costa MG (1980a) Unimpaired delayed type hypersensitivity reactions in mice infected withT. cruzi strain Y. Z Parasitenkd 61:179–185

    Google Scholar 

  • Corsini AC, Oliveira OLP, Costa MG (1980c) Humoral suppression inTrypanosoma cruzi infection in relation to the timing of antigen presentation. Z Parasitenkd 64:85–95

    Google Scholar 

  • Corsini AC, Stelini Jr. A (1981) Immune T cells controlTrypanosoma cruzi infections. Experientia 37:904–906

    Google Scholar 

  • Goble FC (1970) South American Trypanosomes. In: Jackson GJ, Herman R and Singer I (eds) Immunity to Parasitic Animals. Appleton-Century-Croft, New York, Vol II, pp 597–689

    Google Scholar 

  • Kierszenbaum F, Howard JG (1976) Mechanisms of resistance against experimentalT. cruzi infection: the importance of antibodies and antibody — forming capacity in the Biozzi high and low responder mice. J Immunol 116:1208–1211

    Google Scholar 

  • Macedo V (1980) Forma Indeterminada da Doença de Chagas. J Bras de Medicina 38:34–40

    Google Scholar 

  • Ortiz-Ortiz L, Parks DE, Rodriguez M, Weigle WO (1980) Polyclonal B lymphocyte activation duringTrypanosoma cruzi infection. J Immunol 124:121–124

    Google Scholar 

  • Pizzi T, Agostin M, Christen R, Hoecker G, Neghme A (1949) Estudios sobre immunobiologia de las enfermidades parasitarias: I. Influencia de la constitucion genetica en la resistencia de las lanchas a la infection experimental porTrypanosoma cruzi. Boletin Informaciones Parasitarias Chilenas 4:48–49

    Google Scholar 

  • Roberts JJ, Brent TP, Crathorn AR (1971) Evidence for the inactivation and repair of the mammalian DNA template after alkylation by mustard gas and half mustard gas. Europ J Cancer 7:515–524

    Google Scholar 

  • Segal S, Cohen IR, Feldman M (1972) Thymus derived lymphocytes: humoral and cellular reactions distinguished by hydrocortisone. Science 175:1126–1128

    Google Scholar 

  • Siqueira M, Bandieri A, Reis MS, Sant'Anna OA, Biozzi G (1976) Selective breeding of mice for antibody responsiveness to flagellar and somatic antigens ofSalmonellae. Eur J Immunol 6:241–249

    Google Scholar 

  • Takehara HA, Perini A, da Silva MH, Mota I (1981)Trypanosoma cruzi: role of different antibody classes against infection in the mouse. Exp Parasitol 52:137–146

    Google Scholar 

  • Trischman T, Tanowitz H, Wittner M, Bloom B (1978)Trypanosoma cruzi: role of the immune response in the natural resistance of inbred strains of mice. Exp Parasitol 45:160–168

    Google Scholar 

  • WHO (1979) Special Programme for Research and Training in Tropical Diseases — Third Annual Report

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Corsini, A.C., Braz, R., Ciampi, D.B. et al. Resistance toTrypanosoma cruzi infection in relation to the timing of IgG humoral response. Z. Parasitenkd. 68, 15–25 (1982). https://doi.org/10.1007/BF00926653

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00926653

Keywords