Abstract
Male C57L/J mice were infected subcutaneously in the left flank with 10 cysts ofEchinococcus multilocularis. The draining and contralateral nodes were excised at weekly intervals, weighed, and examined histologically. Lymphoproliferation occurred in both the follicles and the paracortex (PCA) of the draining lymph nodes at one week postinfection (p.i.). Disorganization in the PCA of the draining nodes, was characterized by replacement of lymphocytes by plasma cells and the flattening of the endothelial cells lining the postcapillary venules. This began at three weeks p.i. and was completed by 12 weeks p.i. No comparable alterations occurred in the contralateral nodes during this period, but at 22 weeks p.i. these nodes were disorganized and histologically identical to the draining nodes. The growth and histogenesis of the subcutaneous alveolar cysts correlated with the expansion and disorganization of the PCA. The regulation of subcutaneous murine alveolar hydatidosis is discussed with reference to immune-deviation which is brought about by the antigenic load and plasmacellular infiltration in the draining lymph nodes
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alexander, P., Bensted, J., Delorme, E.J., Hall, J.G., Hodgett, J.: The cellular immune response to primary sarcomata in rats. II. Abnormal responses of nodes draining the tumor. Proc. Roy. Soc. Lond. [Biol.]174, 237–251 (1969)
Ali-Khan, Z.: Host-parasite relationship in echinococcosis. I. Parasite biomass and antibody response in three strains of inbred mice against graded doses ofEchinococcus multilocularis cysts. J. Parasitol.60, 231–235 (1974a)
Ali-Khan, Z.: Host-parasite relationship in echinococcosis. II. Cyst weight, hematologic alterations and gross changes in the spleen and lymph nodes of C57/L mice against graded doses ofEchinococcus multilocularis cysts. J. Parasitol.60, 235–242 (1974b)
Ali-Khan, Z.: Glutaraldehyde fixed-antigen sensitized stable cells in indirect hemagglutination test for rapid diagnosis of hydatid diseases, trichinosis and amoebiasis. Int. J. Parasitol.4, 549–555 (1974c)
Ali-Khan, Z.: Cellular changes in the lymphoreticular tissues of C57L/J mice infected withEchinococcus multilocularis cysts. Immunology34, 831–839 (1978a)
Ali-Khan, Z.: Pathological changes in the lymphoreticular tissues of Swiss mice infected withEchinococcus granulosus cysts. Z. Parasitenkd.58, 47–54 (1978b)
Ali-Khan, Z.:Echinococcus multilocularis: Cell mediated immune response in early and chronic alveolar murine hydatidosis. Exp. Parasitol.46, 157–165 (1978c)
Ali-Khan, Z.: Humoral response to sheep red blood cells in C57L/J mice during early and chronic stages of infection withEchinococcus multilocularis cysts. Z. Parasitenkd.59, 259–265 (1979)
Ali-Khan, Z., Siboo, R.: Pathogenesis and host response in subcutaneous alveolar hydatidosis. I. Histogenesis of alveolar cyst and a qualitative analysis of the inflammatory infiltrates. Z. Parasitenkd.62, 241–254 (1980)
Baillif, R.N., Jones, E.L.: The mediastinal nodes of immunized mice with induced pulmonary carcinoma. J. Reticuloendothel. Soc.6, 313–332 (1969)
Baron, R.W., Tanner, C.E.: The effect of immunosuppression on secondaryEchinococcus multilocularis infection in mice. Int. J. Parasitol.6, 37–42 (1976)
Bartlett, A., Turk, J., Ngu, J., Mackenzie, C.D., Fuglsang, H.: Variation in delayed hypersensitivity in onchocerciasis. Trans. R. Soc. Trop. Med. Hyg.72, 372–377 (1978)
Cochrane, C.G., Koffler, D.: Immune complex disease in experimental animals and man. Adv. Immunol.16, 185–264 (1973)
Davies, A.J.S., Carter, R.L., Leuchars, E., Wallis, V., Dietrich, E.M.: The morphology of immune reactions in normal, thymectomized and reconstituted mice. III. The response to bacterial antigens: salmonella flagellar antigen and pneumococcal polysaccharide. Immunology19, 945–957 (1970)
Dixon, J.B., Jenkins, P., Allan, D.: Blastic stimulation of unprimed mouse lymphocytes by living protoscolices ofEchinococcus granulosus: a possible connection with transplant immunity. J. Parasitol.61, 949–950 (1978)
Edwards, A.J., Summer, M.R., Rowlands, G.F., Hurd, C.M.: Changes in lymphoreticular tissues during growth of a murine adenocarcinoma. I. Histology and weight of lymph nodes, spleen and thymus. J. Nat. Cancer Inst.47, 301–309 (1971)
Feldman, J.D.: Immunological enhancement: A study of blocking antibodies. Adv. Immunol.15, 167–205 (1972)
Hinz, E.: Befall mitEchinococcus multilocularis und Antikörpertiter bei intraperitoneal und subkutan infizierten NMRI-Mäusen. Tropenmed. Parasitol.24, 198–206 (1973)
Mannik, M., Arend, W.P.: Fate of preformed immune complexes in rabbits and rhesus monkeys. J. Exp. Med.134, 195–315 (1971)
Nath, L., Curtis, J., Bhutani, L.K., Talwar, G.P.: Reduction of a subpopulation of T lymphocytes in lepromatous leprosy. Clin. Exp. Immunol.18, 81–87 (1974)
Oort, J., Turk, J.L.: A histological and autoradiographic study of lymph nodes during the development of contact sensitivity in the guinea pig. Brit. J. Exp. Pathol.46, 147–154 (1965)
Ottesen, E.A., Weller, P.F., Heck, L.: Specific cellular immune unresponsiveness in human filariasis. Immunology33, 413–421 (1977)
Parrott, D.M.V., DeSousa, M.: Thymus-dependent and thymus-independent populations: origin, migratory pattern and life span. Clin. Exp. Immunol.8, 663–684 (1971)
Risdall, R.J., Aust, J.C., Mekhann, C.F.: Immune capacity and response to antigenic tumors. Cancer Res.33, 2078–2085 (1973)
Rook, G.A.W.: The immunological consequences of antigen overload in experimental mycobacterial infections of mice. Clin. Exp. Immunol.19, 167–177 (1975)
Stanislawski, L., Stanislawski, M.: Kinetics of the plasmacellular reaction in the draining lymph node of mice bearing the BP-8 fibrosarcoma. Cancer Res.36, 3020–3024 (1976)
Varela-Diaz, V.M., Eckert, J., Rausch, R.L., Coltorti, E.A., Hess, U.: Detection ofEchinococcus granulosus diagnostic arc 5 in sera from patients with surgically confirmedE. multilocularis infection. Z. Parasitenkd.53, 183–188 (1977)
Waksman, B.H.: Cellular hypersensitivity and immunity: conceptual changes in the last decade. Cell Immunol.42, 155–169 (1979)
Author information
Authors and Affiliations
Additional information
This work was supported by a grant (MA-7023) from the Medical Research Council of Canada
Rights and permissions
About this article
Cite this article
Ali-Khan, Z., Siboo, R. Pathogenesis and host response in subcutaneous alveolar hydatidosis. Z. Parasitenkd. 62, 255–265 (1980). https://doi.org/10.1007/BF00926566
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00926566