Abstract
Concurrent infections with two parasites: a nematode,Trichinella spiralis, and a protozoon,Toxoplasma gondii, were investigated. Antibody production (total immunoglobulin and IgM) was similar in double and single infections. However, the number ofToxoplasma cysts in the brains of mice infected withTrichinella and challenged 1–6 weeks later withToxoplasma was higher than in mice infected withToxoplasma alone, while mice infected withToxoplasma and challenged 4–14 days later withTrichinella had lower worm burdens in the intestine than animals infected withTrichinella alone. Greater loss in body weight was observed in mice infected with both parasites than in those infected with either parasite alone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Araujo, F.G., Nascimento, E.:Trypanosoma cruzi infection in mice chronically infected withToxoplasma gondii. J. Parasitol.63, 1120–1121 (1977)
Barriga, O.O.: Selective immunodepression in mice byTrichinella spiralis extracts and infections. Cell. Immunol.17, 306–309 (1975)
Betz, A.: Diagnostic sérologique de la toxoplasmose au moyen d'antigènes préparés sur cultures cellulaires. Bull. WHO39, 367–374 (1968)
Cypess, R.H., Lubiniecki, A.S., Hammon, W.McD.: Immunosuppression and increased susceptibility to Japanese-B-encephalitis virus inTrichinella spiralis-infected mice. Proc. Soc. Exp. Biol. Med.143, 469–473 (1973)
Cypess, R.H., Lubiniecki, A.S., Swidwa, D.M.: Decreased susceptibility toListeria monocytogenes in mice after infection withTrichinella spiralis. Infect. Immun.9, 477–479 (1974)
Faubert, G.M.: Depression of the plaque-forming cells to sheep red blood cells by the new born larvae ofTrichinella spiralis. Immunology30, 485–489 (1976)
Faubert, G., Tanner, C.E.:Trichinella spiralis: inhibition of sheep haemagglutinins in mice. Exp. Parasitol.30, 120–123 (1971)
Gentry, O.L., Remington, J.S.: Resistance againstCryptococcus conferred by intracellular bacteria and protozoa. J. Infect. Dis.123, 22–31 (1971)
Huldt, G., Gard, S., Olovson, S.G.: Effect ofToxoplasma gondii on the thymus. Nature244, 301 (1973)
Kilham, L., Olivier, L.: The promoting effect of trichinosis on encephalomyocarditis (EMC) virus infection in rats. Am. J. Trop. Med. Hyg.10, 879–889 (1961)
Lubiniecki, A.S., Cypess, R.H.: Immunological sequelae ofTrichinella spiralis infection in mice: effect on the antibody response to sheep erythrocytes and Japanese-B-encephalitis virus. Infect. Immun.11, 1306–1311 (1975)
Lubiniecki, A.S., Cypess, R.H., Lucas, J.P.: Synergistic interaction of two agents in mice: Japanese-B-encephalitis virus andTrichinella spiralis. Am. J. Trop. Med. Hyg.23, 235–241 (1974)
Mahmoud, A.A.F., Warren, K.S., Strickland, G.T.: Acquired resistance to infection withSchistosoma mansoni induced byToxoplasma gondii. Nature263, 56–67 (1976)
Pelster, B.: Histopathologische Untersuchung an Thymus und Milz nach experimentellerToxoplasma-Infektion von Maus, Ratte undMastomys natalensis. Eine vergleichende licht- und elektronenmikroskopische Studie. Habilitationsschrift, Med. Fak. Univ. Bonn (1978)
Pereverzeva, E.C., Ozeretskovskaya, N.N., Veretennikova, N.L.: Effects of phytohaemagglutinin in experimental trichinellosis. In: Trichinellosis, proceedings of the 3rd International Conference on Trichinellosis., E.W. Kim, ed., pp. 111–121. New York: Intext Educational Publishers 1974
Remington, J.S., Merigan, T.C.: Resistance to virus challenge in mice infected with protozoa or bacteria. Proc. Soc. Exp. Biol. Med.131, 1184–1188 (1969)
Saathoff, M., Piekarski, G.: Über die Gewinnung einer geeignetenToxoplasma-Suspension für den Sero-Farbtest. Zentralbl. Bakteriol [Orig. A]202, 117–131 (1967)
Stahl, W., Matsubayashi, H., Akao, S.: Modification of subclinical toxoplasmosis in mice by cortisone 6-mercaptopurine and splenectomy. Am. J. Trop. Med. Hyg.15, 869–874 (1966)
Strickland, G.T., Voller, A., Pettit, L.E., Fleck, D.G.: Immunodepression associated with concomitantToxoplasma and malarial infections in mice. J. Infect. Dis.126, 54–60 (1972)
Strickland, G.T., Pettit, L.E., Voller, A.: Immunodepression in mice infected withToxoplasma gondii. Am. J. Trop. Med. Hyg.22, 452–455 (1973)
Wakelin, D., Wilson, M.M.: Transfer of immunity toTrichinella spiralis in the mouse with mesenteric lymph node cells: time of appearance of effective cells in donors and expression of immunity in recipients. Parasitology74, 215–224 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yusuf, J.N., Piekarski, G. & Pelster, B. Concurrent infections ofTrichinella spiralis andToxoplasma gondii in mice. Z. Parasitenkd. 62, 231–240 (1980). https://doi.org/10.1007/BF00926564
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00926564