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Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency


The effect of thalidomide on circulating cytokines and myocardial lesion formation was investigated in Mg-deficient rats. After two weeks on a Mg-deficient diet, rats show an increase in circulating levels of tumor necrosis factor-alpha and interleukin 1. Thalidomide (1 mg/day) caused a complete inhibition of the increase in circulating tumor necrosis factor-alpha levels, without having an effect on interleukin 1. However, a marked increase in cardiomyopathic lesion formation was observed in Mg-deficient animals treated with thalidomide; possible mechanisms for thalidomide's enhancement of myocardial injury are discussed. (Mol Cell Biochem129: 195–200, 1993)

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Correspondence to William B. Weglicki.

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Weglicki, W.B., Stafford, R.E., Dickens, B.F. et al. Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency. Mol Cell Biochem 129, 195–200 (1993).

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Key words

  • magnesium-deficiency
  • rats
  • tumor necrosis factor
  • thalidomide
  • interleukin-1
  • myocardial necrosis