Molecular and Cellular Biochemistry

, Volume 137, Issue 1, pp 57–60 | Cite as

Effect of aluminium (Al) on brain mitochondrial monoamine oxidase-A (MAO-A) activity — anin vitro kinetic study

  • K. S. Jagannatha Rao
  • Gazula Valeswara Rao


Effect of aluminium (Al) on rat brain mitochondrial monoamine oxidase-A (MAO-A) was studiedin vitro at three different pH (4.0, 7.4 and 9.0) values. The results have shown that Al is a non-competitive inhibitor for MAO-A. The data also showed that MAO-A inhibition by Al varies with free Al3+ concentration and different forms of Al under different pH conditions. Al altered the maximum velocity (Vmax) of MAO-A but did not affect substrate-enzyme affinity (Km). Al formed a strong chelation with the substrate (Kynuramine) (1:1).

Key words

aluminium monoamine oxidase kynuramine 


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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • K. S. Jagannatha Rao
    • 1
  • Gazula Valeswara Rao
    • 1
  1. 1.Department of Biochemistry and NutritionCentral Food Technological Research InstituteMysoreIndia

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