Molecular and Cellular Biochemistry

, Volume 120, Issue 1, pp 25–32 | Cite as

Neoplastic association of enhanced type V collagen production in rat fibrosarcoma

  • R. Asokan
  • G. Kesava Reddy
  • S. C. Dhar
Article

Abstract

Collagens present in the connective tissues of the extracellular matrix of fibrosarcoma were isolated and characterized. The fibrosarcoma was induced in rats by the administration of 3-methylcholanthrene. The results obtained were compared with normal muscle. An excess amount of type V collagen was found to be produced by the fibrosarcoma tissue compared to the normal muscle. Type V collagen from fibrosarcoma was characterized on the basis of solubility behavior in sodium chloride solutions, electrophoretic mobility on SDS-polyacrylamide gels, elution pattern of phosphocellulose chromatography and amino acid composition.

Key words

extracellular matrix collagen fibrosarcoma 

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Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • R. Asokan
    • 1
  • G. Kesava Reddy
    • 1
  • S. C. Dhar
    • 1
  1. 1.Department of BiochemistryCentral Leather Research InstituteMadrasIndia

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