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Reaction of 8-substitute d 3-phenyl-5-methyl-2-oxa-1-aza-bicyclo[3.3.0]octanes with nucleophilic reagents

  • I. E. Chlenov
  • Yu. B. Salamonov
  • V. A. Tartakovskii
Brief Communications

Conclusions

  1. 1.

    When 5-methyl-3-phenyl-8-hydroxy-2-oxa-1-azabicyclo[3.3.0]octane is reacted with methanol and propylamme the hydroxyl group is respectively replaced by the methoxy and N-propylamine group.

     
  2. 2.

    5-Methyl-3-phenyl-8-(N-propylamino)-2-oxa-1-azabicyclo[3.3.0]octane reacts with methyl nitroacetate and ethyl cyanoacetate without a catalyst, and with acetylacetone and acetoacetic ester in the presence of BF3 etherate as the catalyst, to give condensation products.

     

Keywords

Methyl Methanol Ester Ethyl Hydroxyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

  1. 1.
    General Handbook on Organic Chemistry [in Russian], Mir (1965), p. 429.Google Scholar
  2. 2.
    C. K. Ingold, Structure and Mechanism in Organic Chemistry, Cornell Univ. Press (1969).Google Scholar
  3. 3.
    A. Hantzsch and A. Veit, Ber.,32, 607 (1899).Google Scholar
  4. 4.
    I. E. Chlenov, L. N. Kolymagina, and V. A. Tartakovskii, Izv. Akad. Nauk SSSR, Ser. Khim., 1893 (1972).Google Scholar
  5. 5.
    I. E. Chlenov, N. S. Morozova, V. I. Khudak, and V. A. Tartakovskii, Izv. Akad. Nauk SSSR, Ser. Khim., 2641 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • I. E. Chlenov
    • 1
  • Yu. B. Salamonov
    • 1
  • V. A. Tartakovskii
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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