Zeitschrift für Parasitenkunde

, Volume 61, Issue 3, pp 265–269 | Cite as

Phospholipase B activity in congenitally athymic (nude) mice infected withTrichinella spiralis

  • Arthur J. Goven
  • George W. Moore
Original Investigations

Abstract

The effects of an infection with 200Trichinella spiralis larvae on the intestinal phospholipase B activity and bone marrow eosinophilia of congenitally athymic (nude) mice (BALB/c; NU/NU) were studied. Nude mice were used since it had been shown that they do not undergo a typical worm expulsion and also they lack a thymus. The results showed that nude mice do not develop either an increased bone marrow eosinophilia or an elevation in intestinal phospholipase B activity. The findings thus support the hypothesis that phospholipase B is involved in the expulsion of parasitic worms and that elevated enzyme levels and expulsion are thymus cell dependent.

Key words

Phospholipase B Nude mice Eosinophilia T. spiralis 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Arthur J. Goven
    • 1
  • George W. Moore
    • 1
  1. 1.Department of Parasitology and Laboratory PracticeUniversity of North Carolina at Chapel HillUSA

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