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Stage-specific sensitivity ofPlasmodium falciparum to antifolates

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Abstract

Highly synchronous cultures ofPlasmodium falciparum were exposed to therapeutic concentrations of sulfadoxine or pyrimethamine at different developmental stages to investigate the effect on subsequent growth. Morphological observations showed that schizont formation from uninuclear trophozoites was the only process inhibited by the drugs. Segmentation of mature schizonts, merozoite invasion and development of the ring stage remained unaffected. These results support earlier reports suggesting that DNA synthesis is most pronounced in 32–42 h old trophozoites. The possible relevance of our results to the metabolism ofP. falciparum is discussed.

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Author notes

  1. Angela Dieckmann

    Present address: Abteilung Parasitologie, Universität Hohenheim, Emil-Wolff-Str. 34, D-7000, Stuttgart 70, Germany

Authors and Affiliations

  1. Physiologisch-Chemisches Institut, Universität Tübingen, Hoppe-Seyler-Str. 1, D-7400, Tübingen 1, Germany

    Angela Dieckmann & Albrecht Jung

Authors
  1. Angela Dieckmann
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  2. Albrecht Jung
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Dedicated to Prof. Dr. W. Frank on the occasion of his sixtieth birthday

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Dieckmann, A., Jung, A. Stage-specific sensitivity ofPlasmodium falciparum to antifolates. Z. Parasitenkd. 72, 591–594 (1986). https://doi.org/10.1007/BF00925479

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  • DOI: https://doi.org/10.1007/BF00925479

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