Phenylalanine derivatives containing an acyl residue of the stereoisomeric N-[di(ethylenimino)(thio)phosphoryl]-4-aminocyclohexanecarboxylic acids

  • K. I. Karpayichyus
  • L. A. Patotskene
  • I. L. Knunyants
Organic Chemistry
  • 35 Downloads

Conclusions

  1. 1.

    The most convenient method for the acylation of phenylalanine by N-acyl derivatives of aminocyclohexanecarboxylic acid (ACHCA) employs mixed anhydrides, and protection by the N-carbobenzoxy group is the most convenient method for the blocking of the amino group in ACHCA.

     
  2. 2.

    The ethyl esters of N-[dichloro(thio)phosphoryl]-cis-4-ACHC-DL-phenylalanine, N-[dichlpro(thio)-phosphoryl]-trans-4-ACHC-DL-phenylalanine, N-[di(ethylenimino)(thio)phosphoryl]-cis-4-ACHC-DL-phenylalanine, and N-[di(ethylenimino)(thio)phosphoryl]-trans-4-ACHC-DL-phenylananine, as well as the Na salts of N-[di(ethylenimino)(thio)phosphoryl]-cis-4-ACHC-DL-phenylalanine and N-[di(ethylenimino)(thio)-phosphoryl]-trans-4-ACHC-DL-phenylalanine, have been synthesized.

     

Keywords

Ester Ethyl Anhydride Phenylalanine Ethyl Ester 

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Literature cited

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • K. I. Karpayichyus
    • 1
    • 2
  • L. A. Patotskene
    • 1
    • 2
  • I. L. Knunyants
    • 1
    • 2
  1. 1.Institute of Heteroorganic CompoundsAcademy of Sciences of the USSRMoscow
  2. 2.Institute of BiochemistryAcademy of Sciences of the Lithuanian SSRUSSR

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