Conclusions
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1.
The reaction of 2,5,6-triamino-4-hydroxypyrimidine with acetamidoacetone, its brominatton product, or N,N-diacetylaminoacetone in aqueous solution in the presence of hydrazine gives mixtures of the 6- and 7-methylpterins in an 8∶2 ratio.
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2.
The reaction of 2,5,6-triamino-4-hydroxypyrimidine with acetamidoacetone in aqueous diethylamine solution leads to 7-methylpterin.
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Literature cited
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2811–2813, December, 1977.
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Zav'yalov, S.I., Budkova, T.K. & Ezhova, G.I. Regioselectivity of reaction of N-acetyl-α-aminoketones with 2,5,6-triamino-4-hydroxypyrimidine. Russ Chem Bull 26, 2601–2603 (1977). https://doi.org/10.1007/BF00924581
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DOI: https://doi.org/10.1007/BF00924581