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Effects of a synchronizer phase-shift on circadian rhythms in response of mice to ethanol or ouabain

Space life sciences volume 4, pages 249–257 (1973)Cite this article

Abstract

The percentage of mice dying from a toxic dose of ethanol or ouabain was determined at 4-hour intervals during the first 3 days after inversion of an LD(12:12) lighting regimen. In comparison to unshifted control animals at similar stages of the synchronizer schedule, spans of relative advantage alternated with spans of relative disadvantage due to a gradual phase-shift of the circadian susceptibility rhythm. Overall mortality, determined for an integral number of day, was not obviously affected by the regimen-shift.

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Affiliations

  1. Chronobiology Laboratories, Department of Laboratory Medicine and Pathology, University of Minnesota, Health Sciences Center, 55455, Minneapolis, Minn., USA

    W. Nelson & F. Halberg

Authors
  1. W. Nelson
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  2. F. Halberg
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Additional information

Supported by grants from the United States Public Health Service (5-K6-GM-13,981), NASA (NGR-24-005-006) and the U.S. Air Force (F29600-69-C-0011).

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Nelson, W., Halberg, F. Effects of a synchronizer phase-shift on circadian rhythms in response of mice to ethanol or ouabain. Space Life Sciences 4, 249–257 (1973). https://doi.org/10.1007/BF00924472

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  • DOI: https://doi.org/10.1007/BF00924472

Keywords

  • Organic Chemistry
  • Geochemistry
  • Control Animal
  • Circadian Rhythm
  • Ouabain