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Interaction of methylated iodides of O-alkyl O-β-alkylmercaptoethyl phenylphosphonates with choline esterases

  • Organic Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The kinetics of the interaction of the methylated iodides of O-ethyl O-β-alkylmercaptoethyl phenylphosphonates and methylated iodides of O-alkyl O-β-methylmercaptoethyl phenylphosphonates with acetylcholinesterase and butyrylcholinesterase have been studied.

  2. 2.

    The compounds studied are reversible inhibitors of choline esterases of the competitive type, their inhibitor activity being dependent on the length of the alkoxyl and alkylthiol radicals.

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Literature cited

  1. R. S. Agabekyan, M. Kh. Bekanov, M. Kh. Berkhamov, N. N. Godovikov, and M. I. Eabachnik, Izv. Akad. Nauk SSSR, Ser. Khim., 874 (1974).

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

    M. Kh. Bekanov, N. N. Godovikov, M. Kh. Berkhamov, R. S. Agabekyan, V. M. Kuzamyshev, G. G. Ol'khovaya & M. I. Kabachnik

Authors
  1. M. Kh. Bekanov
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  2. N. N. Godovikov
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  3. M. Kh. Berkhamov
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  4. R. S. Agabekyan
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  5. V. M. Kuzamyshev
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  6. G. G. Ol'khovaya
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  7. M. I. Kabachnik
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2099–2101, September, 1977.

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Bekanov, M.K., Godovikov, N.N., Berkhamov, M.K. et al. Interaction of methylated iodides of O-alkyl O-β-alkylmercaptoethyl phenylphosphonates with choline esterases. Russ Chem Bull 26, 1943–1945 (1977). https://doi.org/10.1007/BF00924395

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  • DOI: https://doi.org/10.1007/BF00924395

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