Reaction of O-ethyl S-(β-a lkylmercaptoethyl) phenylthiophosphonates and their methiodides with cholinesterases

  • M. Kh. Bekanov
  • A. P. Brestkin
  • M. Kh. Berkhamov
  • N. N. Godovikov
  • M. I. Kabachnik
  • O. I. Smirnov
Organic and Biological Chemistry
  • 14 Downloads

Conclusions

  1. 1.

    A study was made of the reaction of some O-ethyl S-(β-alkylmercaptoethyl) phenylthiophosphonates and their methiodides with acefylcholinesterase and butyrylcholinesterase.

     
  2. 2.

    The studied compounds inhibit the catalytic activity of cholinesterases only by the irreversible type of inhibition.

     

Keywords

Catalytic Activity Cholinesterase Methiodides Irreversible Type 

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Literature cited

  1. 1.
    A. P. Brestkin, R. I. Volkova, N. N. Godovikov, and M. I. Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim.,1968, 2028Google Scholar
  2. 2.
    R. I. Volkova, N. A. Kardanov, A. P. Brestkin, N. N. Godovikov, and M. I. Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim.,1973, 2114.Google Scholar
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    I. L. Brik and N. A. Yakovlev Biokhimiya,27, 481 (1962).Google Scholar
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    N. N. Godovikov, M. Kh. Bekanov, M. Kh. Berkhamov, and M. I. Kabachnik, Zh. Obshch. Khim.,44, 34 (1974).Google Scholar
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    T. A. Mastryukova, Dissertation [in Russian], Moscow (1967).Google Scholar
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    A. A. Aaviksaar, Dissertation [in Russian], Tartu (1968).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • M. Kh. Bekanov
    • 1
    • 2
    • 3
  • A. P. Brestkin
    • 1
    • 2
    • 3
  • M. Kh. Berkhamov
    • 1
    • 2
    • 3
  • N. N. Godovikov
    • 1
    • 2
    • 3
  • M. I. Kabachnik
    • 1
    • 2
    • 3
  • O. I. Smirnov
    • 1
    • 2
    • 3
  1. 1.Institute of Heteroorganic Compounds of the Academy of Sciences of the USSRMoscow
  2. 2.I. M. Sechenov Institute of Evolutional Physiology and BiochemistryAcademy of Sciences of the USSRLeningrad
  3. 3.Kabardino-Balkarsk State UniversityNal'chik

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