Conclusions
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1.
The 3′(2′)-O-amino acid esters of adenosine 5′-phosphate were synthesized employing the N-imidazolides of N-protonated amino acids.
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2.
It was shown that the N-imidazolides of N-protonatedα-amino acids were relatively stable, and that the N-imidazolides of protonated amino acids, where the amino group is more than one carbon atom away from the carboxyl, polymerize rapidly.
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3.
The 1,2,4-triazolides of N-protected and N-protonated amino acids do not react in aqueous medium with adenosine 5′-phosphate. The triazolides of the N-protonated amino acids do not polymerize.
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See [1] for Communication 12.
Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 8, pp. 1856–1859, August, 1974.
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Kraevskii, A.A., Tarusova, N.B., Tsilevich, T.L. et al. Amino acid derivatives of nucleosides, nucleotides, and polynucleotides. Russ Chem Bull 23, 1776–1779 (1974). https://doi.org/10.1007/BF00923210
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DOI: https://doi.org/10.1007/BF00923210