Skip to main content
SpringerLink
Log in

Decomposition of blood group substance H in alkaline sodium borohydeide solution

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

The degradation of BGS H in alkaline NaBH4 solution is accompanied by the destruction of ∼40% of the galactosamine residues that are found in the node of the carbohydrate-peptide linkage. The other monosaccharides are not affected here, which makes it possible to use this procedure to obtain the carbohydrate chains of BGS with a minimum degree of degradation. Oligosaccharides with a variable molecular weight (from 500 to 3000 and higher) are formed as a result of the degradation, which indicates the great heterogeneity of the carbohydrate chains of the BGS. A number of the oligosaccharides was isolated in the pure state.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. K. O. Lloyd and E. A. Kabat, Biochem. Biophys. Res. Commun.,16, 385 (1964).

    Google Scholar 

  2. J. W. Moye and D. M. Carlson, Carbohydr. Res.,15, 300 (1970).

    Google Scholar 

  3. R. N. Iyer and D. M. Carlson, Arch. Biochem. Biophys.,142, 101 (1971).

    Google Scholar 

  4. B. Anderson, L. Rovis, and E. A. Kabat, Arch. Biochem. Biophys.,148, 304 (1972).

    Google Scholar 

  5. L. Rovis, B. Anderson, E. A. Kabat, F. Gruezo, and J. Liao, Biochemistry,12, 2155 (1973).

    Google Scholar 

  6. V. A. Derevitskaya, O. S. Novikova, and N. K. Kochetkov, Dokl. Akad. Nauk SSSR,216, 804 (1974).

    Google Scholar 

  7. L. M. Likhosherstov, V. A. Derevitskaya, and V. I. Fedorova, Biokhimiya,34, 45 (1969).

    Google Scholar 

  8. V. A. Derevitskaya, L. M. Likhosherstov, S. N. Senchenkova, and N. K. Kochetkov, Izv. Akad. Nauk SSSR, Ser. Khim., 2067 (1970).

  9. S. N. Senchenkova, Dissertation [in Russian], Moscow (1972).

  10. V. A. Derevitskaya, L. M. Likhosherstov, N. P. Arbatskii, and N. K. Kochetkov, Izv. Akad. Nauk SSSR, Ser. Khim., 2782 (1972).

  11. V. A. Derevitskaya, L. M. Likhosherstov, S. A. Medvedov, and N. K. Kochetkov, Dokl. Akad. Nauk SSSR,213, 220 (1973).

    Google Scholar 

  12. D. M. Marcus, E. A. Kabat, and G. Schiffman, Biochemistry,3, 437 (1964).

    Google Scholar 

  13. M. L. Zarnitz and E. A. Kabat, J. Am. Chem. Soc.,82, 3952 (1960).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    V. A. Derevitskaya, N. P. Arbatskii & N. K. Kochetkov

Authors
  1. V. A. Derevitskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. P. Arbatskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. K. Kochetkov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1163–1167, May, 1975.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Derevitskaya, V.A., Arbatskii, N.P. & Kochetkov, N.K. Decomposition of blood group substance H in alkaline sodium borohydeide solution. Russ Chem Bull 24, 1069–1073 (1975). https://doi.org/10.1007/BF00922967

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00922967

Keywords

Search

Navigation