Journal of Clinical Immunology

, Volume 1, Issue 3, pp 169–173 | Cite as

Autoimmunity in type I (insulin-dependent) diabetes mellitus in North India

  • S. Srikanta
  • A. N. Malaviya
  • N. K. Mehra
  • M. C. Vaidya
  • P. J. Geevarghese
  • M. M. S. Ahuja
Original Articles

Abstract

Pancreatic islet cell, thyroid, gastric parietal cell, and adrenal autoantibodies were studied in 110 young insulin-dependent diabetics (Type I; IDDM), 12 non-insulin-dependent diabetics (NIDDM), 26 patients with pancreatic diabetes, and 123 age- and sex-matched healthy controls. All the patients were aged 30 years or under at the onset of diabetes. Islet cell antibody was found in 31% of the patients with IDDM, but in only one patient with NIDDM, one patient with pancreatic diabetes, and one healthy control subject. Thyroid, parietal cell, and/or adrenal antibodies were present in 26% of the IDDM patients, 17% of the NIDDM patients, 12% of the patients with pancreatic diabetes, and 19% of the control subjects. There was no association between the presence of islet cell antibody and other organ-specific autoantibodies and any particular HLA phenotype. Data from the North Indian study have been compared with those from other populations of the world, similarities and differences have been brought out, and their significance has been discussed. The relative contribution of the autoimmune component in the etiopathogenesis of different forms of diabetes mellitus varies among the different populations of the world, accounting to some extent for the observed differences in incidence and clinical profiles.

Key words

Insulin-dependent diabetes mellitus islet cell antibody organ-specific autoantibody HLA 

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References

  1. 1.
    Cudworth AG: The aetiology of diabetes.In Advanced Medicine—13, M. Besser (ed). England, Pitman Medical, 1978, pp. 163–172Google Scholar
  2. 2.
    Bottazzo GF, Doniach D: Autoimmunity in diabetes mellitus.In Secondary Diabetes: The Spectrum of the Diabetic Syndomes, S. Podolsky and M. Viswanathan (eds). New York, Raven Press, 1980, pp 391–408Google Scholar
  3. 3.
    Drash AL: The etiology of diabetes mellitus. N Engl J Med 300(21):1211–1213, 1979Google Scholar
  4. 4.
    Ahuja MMS, Kumar V: Diabetes mellitus in the Indian scene.In Progress in Clinical Medicine in India, MMS Ahuja (ed). New Delhi, Arnold Heinemann, 1975, pp 538–560Google Scholar
  5. 5.
    McMillan DE, Geevarghese PJ: Dietary cyanide and tropical malnutrition diabetes. Diabetes Care 2:202–208, 1979Google Scholar
  6. 6.
    Bala K, Malaviya AN, Bhuyan UN, Kumar R: Profile of autoantibodies in autoimmune diseases in India. Ind J Med Res 66:957–964, 1977Google Scholar
  7. 7.
    Bottazzo GF, Florin-Christensen A, Doniach D: Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiences. Lancet 2:1279–1283, 1974Google Scholar
  8. 8.
    Terasaki PI, McClelland JD: Microdroplet assay of human serum cytotoxins. Nature 204:998–1000, 1964Google Scholar
  9. 9.
    Srikanta S, Mehra NK, Vaidya MC, Malaviya AN, Ahuja MMS: HLA antigens in Type I (insulin-dependent) diabetes mellitus in North India. Metabolism (in press)Google Scholar
  10. 10.
    Irvine WJ, McCallum CJ, Gray RS, Campbell CJ, Duncan LJP, Farquhar JW, Vaughan H, Morris PJ: Pancreatic islet cell antibodies in diabetes mellitus correlated with the duration and type of diabetes, coexistent autoimmune disease, and HLA type. Diabetes 26:138–147, 1977Google Scholar
  11. 11.
    Lendrum R, Walker G, Cudworth AG, Woodrow JC, Gamble DR: HLA-linked genes and islet cell antibodies in diabetes mellitus. Br Med J 1:1565–1567, 1976Google Scholar
  12. 12.
    Del Prete GF, Betterle C, Padovan D, Erle C, Toffolo A, Bersani G: Incidence and significance of islet cell autoanitbodies in different types of diabetes mellitus. Diabetes 26:909–915, 1977Google Scholar
  13. 13.
    Irvine WJ: The immunology and genetics of autoimmune endocrine disease.In Genetic Control of Autoimmune Disease, NR Rose, PE Bigazzi, NL Warner (eds). New York, Elsevier/North Holland, 1978, pp 77–100Google Scholar
  14. 14.
    Knowler WC, Bennett PH, Botazzo GF, Doniach D: Islet cell antibodies and diabetes mellitus in Pima Indians. Diabetologia 17:161–164, 1979Google Scholar
  15. 15.
    Neufeld M, Maclaren N, Riley W: Islet cell and other organspecific antibodies in U.S. Caucasians and blacks with insulin-dependent diabetes mellitus. Diabetes (in press).Google Scholar
  16. 16.
    Bottazzo GF, Cudworth AG, Moul DJ, Doniach D, Festenstein H: Evidence for a primary autoimmune type of diabetes mellitus. Br Med J 2:1253–1255, 1978Google Scholar

Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • S. Srikanta
    • 1
  • A. N. Malaviya
    • 1
  • N. K. Mehra
    • 2
  • M. C. Vaidya
    • 2
  • P. J. Geevarghese
    • 3
  • M. M. S. Ahuja
    • 1
  1. 1.Department of Medicine, Division of Endocrinology and Clinical ImmunologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of Anatomy, Cellular Immunology LaboratoryAll India Institute of Medical SciencesNew DelhiIndia
  3. 3.Department of MedicineKottayam Medical CollegeKottayamIndia

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