Advertisement

Urological Research

, Volume 20, Issue 5, pp 361–363 | Cite as

Periurethral colonization and urinary leukocytes as markers for bacteriuria in children with neurogenic bladder

  • T. A. Schlager
  • S. A. Dilks
  • J. A. Lohr
  • G. F. Hayden
  • J. A. Kopco
  • J. W. Hendley
Original Articles

Summary

Bacteriuria and associated renal damage is common in children with a neurogenic bladder, but the pathogenesis of urinary tract infection (UTI) is undefined. We examined the association between periurethral bacterial colonization and the presence of urinary leukocytes in 76 catheter urine specimens from children with neurogenic bladders. Although all the children were asymptomatic, 38/76 (50%) of the urine cultures were positive. Periurethral colonization was significantly more common with positive than with negative urine cultures, suggesting a pathogenetic role for periurethral bacteria in infection of the neurogenic bladder. Urinary leukocytes were present in 24/38 (63%) with positive cultures, as against none (0/38) of those with negative urine cultures, and their presence represents a host response to bladder bacteriuria.

Key words

Bacteriuria Urinary tract infection Neurogenic bladder 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Anderson RU, Hsieh-Ma ST (1983) Association of bacteriuria and pyuria during intermittent catheterization after spinal cord injury. J Urol 130:299Google Scholar
  2. 2.
    Bollgren I, Winberg J (1976) The periurethralaerobic flora in girls highly susceptible to urinary infections. Acta Paediatr Scand 65:81Google Scholar
  3. 3.
    Brem AS, Martin D, Callaghan J, Maynard J (1987) Long-term renal risk factors in children with meningomyelocele. J Pediatr 110:51Google Scholar
  4. 4.
    Cass AS, Luxenberg M, Johnson CF, Gleich P (1985) Incidence of urinary tract complications with myelomeningocele. Urol 25:374Google Scholar
  5. 5.
    Cooper DGW (1967) Urinary tract infection in children with myelomeningocele. Arch Dis Child 42:521Google Scholar
  6. 6.
    Czerwinski AW, Wilkerson RG, Merrill JA, Braden B, Colmore JP (1971) Further evaluation of the Griess test to detect significant bacteriuria. Am J Obstetr Gynecol 110:677Google Scholar
  7. 7.
    Kass EH, Finland M (1956) Asymptomatic infections of the urinary tract. New Jersey: Trans Assoc Am Physicians 56Google Scholar
  8. 8.
    Kunin CM (1987) Detection, prevention and management of urinary tract infections, 4th edn. Lea & Febiger, Philadelphia, p57Google Scholar
  9. 9.
    Kusumi RK, Penelope GJ, Kunin CM (1981) Rapid detection of pyuria by leukocyte esterase activity. JAMA 245:1653Google Scholar
  10. 10.
    Selander RK, Caugant DA, Ochman H, Musser JM, Gilmour MN, Whittam TS (1986) Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. Appl Environ Microbiol 51:873Google Scholar
  11. 11.
    Stamey TA, Sexton C (1975) The role of vaginal colonization with Enterobacteriaceae in recurrent urinary infections. J Urol 113:214Google Scholar
  12. 12.
    Whittam TS, Wolfe ML, Wilson RA (1989) Genetic relationships amongEschericia coli isolates causing urinary tract infections in humans and animals. Epidemiol Infect 102:37Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. A. Schlager
    • 1
  • S. A. Dilks
    • 1
  • J. A. Lohr
    • 1
  • G. F. Hayden
    • 1
  • J. A. Kopco
    • 1
  • J. W. Hendley
    • 1
  1. 1.Department of Pediatrics, Children's Medical CenterUniversity of VirginiaCharlottesvilleUSA

Personalised recommendations