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Certain O, O-dialkyl-S-(β-N,N-cyclohexylmethylaminoethyl)thiophosphates, selective inhibitors of butyrylcholinesterase

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    O,O-Diisopropyl-, O,O-dipropyl, and O,O-dibutyl-S-(β-N, N-cyclohexy]methylaminoethyl)thiophosphates and their methiodides were synthesized and their anticholinesterase activity was determined in relation to butyrylcholinesterase from horse blood serum and acetylcholinesterase from human erythrocytes.

  2. 2.

    O,O-Diisopropyl-S-(β-N, N-cyclohexylmethylammoethyl)thiophosphate and its methiodide display the largest effect of selective effect in relation to butyrylcholinesterase.

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Literature cited

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds of the Academy of Sciences of the USSR, Moscow

    A. P. Brestkin, I. L. Brik, L. I. Ginetsinskaya, N. N. Godovikov, M. I. Kabachnik, E. G. Kireeva & S. A. Trifonova

  2. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Academy of Sciences of the USSR, Leningrad

    A. P. Brestkin, I. L. Brik, L. I. Ginetsinskaya, N. N. Godovikov, M. I. Kabachnik, E. G. Kireeva & S. A. Trifonova

Authors
  1. A. P. Brestkin
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  2. I. L. Brik
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  3. L. I. Ginetsinskaya
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  4. N. N. Godovikov
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  5. M. I. Kabachnik
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  6. E. G. Kireeva
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  7. S. A. Trifonova
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Additional information

Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 4, pp. 883–886, April, 1976.

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Brestkin, A.P., Brik, I.L., Ginetsinskaya, L.I. et al. Certain O, O-dialkyl-S-(β-N,N-cyclohexylmethylaminoethyl)thiophosphates, selective inhibitors of butyrylcholinesterase. Russ Chem Bull 25, 861–864 (1976). https://doi.org/10.1007/BF00922397

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  • DOI: https://doi.org/10.1007/BF00922397

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