Abstract
Nineteen patiens (20 eyes) with the exudative form of macular degeneration were treated with parenteral interferon alfa-2a. Fifteen patients (16 eyes) had adequate follow-up for evaluation of outcome of the exudative macular lesion. The average follow-up was 8 months (range 5-11 months). Color photographs and fluorescein angiograms were evaluated independently by two masked readers for change in size, presence of fibrosis, and leakage of the neovascular lesion. During the follow-up, none of the exudative lesions resolved: one lesion became smaller, four remained the same, nine enlarged, and two could not be graded based on the photographs. Visual acuity remained 20/40 or better in four eyes. The proportion of eyes with visual acuity of 20/200 or worse increased from 35% at the initial visit to 59 % at the final visit. Ten patients experienced significant but reversible side effects, including weight loss, depression, and/or hematopoietic suppression. The data from these cases do not support any significant treatment benefit from interferon alfa-2a at the doses used in exudative macular degeneration.
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References
Abrams DI, Volberding PA (1986) Alpha interferon therapy of AIDS-associated Kaposi's sarcoma. Semin Oncol 13 [Suppl 2]:43–47
Bressler NM, Frost LA, Bressler SB, et al. (1988) Natural course of poorly defined choroidal neovascularization associated with macular degeneration. Arch Ophthalmol 106:1537–1542
Brouty-Boyé D, Zetter BR (1980) Inhibition of cell motility by interferon. Science 208:516–518
Claessens DA, Miller JW, Woods WJ, Folkman J (1992) Alpha-interferon treatment of experimental choroidal neovascularization. ARVO abstracts. Invest Ophthalmol Vis Sci 33:1207
Folkman J (1989) Successful treatment of an angiogenic disease. N Engl J Med 320:1211–1212
Friesel R, Komoriya A, Maciag T (1987) Inhibition of endothelial cell proliferation by gamma-interferon. J Cell Biol 104:689–696
Fung WE (1991) Interferon Alpha 2a for treatment of agerelated macular degeneration. Am J Ophthalmol 112:349–350
Gass JDM (1984) Serous retinal pigment epithelial detachment with a notch: a sign of occult choroidal neovascularization. Retina 4:205–220
Heyns A duP, Elder A, Vlodavsky I, Kaiser N, Fridman R, Panet H (1985) The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events. Studies with vascular smooth muscle cells and endothelial cells. Exp Cell Res 161:297–306
Lewis ML, Pautler S (1988) Retinal pigment epithelial detachments with choroidal neovascular membranes in age-related macular degeneration: natural history versus laser photocoagulation. In: Gitter KA, Schatz H, Yannuzzi LA, McDonald HR (eds) Laser photocoagulation of retinal disease. Pacific Medical Press, San Francisco, pp 207–216
Loughnan MS, Heriot WJ, O'Day J (1992) Treatment of subfoveal choroidal neovascular membranes with systemic interferon-α 2a. Aust NZ J Ophthalmol 20:173–175
Macular Photocoagulation Study Group (1991) Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration: results of a randomized clinical trial. Arch Ophthalmol 109:1220–1231
Singerman LJ, Stockfish JH (1989) Natural history of subfoveal pigment epithelial detachments associated with subfoveal or unidentifiable choroidal neovascularization complicating age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol 227:501–507
Soubrane G, Coscas G, Francais C, Koenig F (1990) Occult subretinal new vessels in age-related macular degeneration: natural history and early laser treatment. Ophthalmology 97:649–657
White CW, Sondheimer HM, Crouch EC, Wilson H, Fan LL (1989) Treatment of pulmonary hemangiomatosis with recombinant interferon alpha-2a. N Engl J Med 320:1197–1200
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Lewis, M.L., Davis, J. & Chuang, E. Interferon alfa-2a in the treatment of exudative age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol 231, 615–618 (1993). https://doi.org/10.1007/BF00921954
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DOI: https://doi.org/10.1007/BF00921954