Conclusions
The aminomethylation, azo-coupling, and nitration of 3-hydroxyisonicotinic acid and its ester are directed to the 2 position, whereas their iodination proceeds with the formation of the 2-iodo and 2,6-diiodo derivatives.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 452–454, February, 1977.
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Smirnov, L.D., Stolyarova, L.G., Shirokova, L.V. et al. Electrophilic reactions of 3-hydroxyisonicotinic acid. Russ Chem Bull 26, 408–410 (1977). https://doi.org/10.1007/BF00921871
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DOI: https://doi.org/10.1007/BF00921871