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Reaction of o-alkyl s-(β-methylmercaptoethyl)phenylthio-phosphonates and their methiodides with cholinesterases

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    A study was made of the kinetics of the inhibition of acetylcholinesterase and butyrylcholinesterase by a number of O-alkyl S-(β-methylmercaptoethyl) phenylthiophos-phonates of the sulfide and sulfonium type.

  2. 2.

    The O-alkyl S-(S-methylmercaptoethyl) phenylthiophosphonates which are irreversible chalinesterase inhibitors, acquire the properties of inhibitors with a combined type of action when the alkyl radical of the alkoxyl group is increased from pentyl to hexyl.

  3. 3.

    The sulfonium O-pentyl and O-hexyl thiophosphonates inhibit only butyrylcholinesterase by the combined mechanism, while irreversible inhibition of the enzyme occurs exclusively in the case of acetylcholinesterase.

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Literature cited

  1. A. P. Brestkin, I. L. Brik, R. I. Volkova, N. N. Godovikov, Kh. Kh. Gurdaliev, M. I. Kabachnik, and N. A. Kardanov, Dokl. Akad. Nauk SSSR,200, 103 (1971).

    Google Scholar 

  2. A. P. Brestkin, R. I. Volkova, N. N. Godovikov, M. I. Kabachnik, and N. A. Kardanov, Izv. Akad. Nauk SSSR, Ser. Khim.,1973, 622.

  3. R. I. Volkova, N. A. Kardanov, A. P. Brestkin, N. N. Godovikov, and M. I. Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim.,1973, 2114.

  4. M. Kh. Bekanov, A. P. Brestkin, M. Kh. Berkhamov, N. N. Godovikov, M. I. Kabachnik, and O. I. Smirnov, Izv. Akad. Nauk SSSR, Ser. Khim.,1974, 2808.

  5. I. L. Brik and V. A. Yakovlev, Biokhimiya,27, 481 (1962).

    Google Scholar 

  6. N. N. Godovikov, M. Kh. Bekanov, M. Kh. Berkhamov, and M. I. Kabachnik, Zh. Obshch. Khim.,44, 1236 (1974).

    Google Scholar 

  7. A. A. Abduvakhabov, N. N. Godovikov, M. I. Kabachnik, L. S. Krivorotova, S. S. Mikhailov, and V. I. Rozengart, Izv. Akad. Nauk SSSR, Ser. Khim.,1972, 1169.

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

    M. Kh. Bekanov, A. P. Brestkin, M. Kh. Berkhamov, N. N. Godovikov, M. I. Kabachnik, O. I. Smirnov & G. G. Ol'khovaya

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  1. M. Kh. Bekanov
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  2. A. P. Brestkin
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  3. M. Kh. Berkhamov
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  4. N. N. Godovikov
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  5. M. I. Kabachnik
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  6. O. I. Smirnov
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  7. G. G. Ol'khovaya
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2573–2576, November, 1975.

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Bekanov, M.K., Brestkin, A.P., Berkhamov, M.K. et al. Reaction of o-alkyl s-(β-methylmercaptoethyl)phenylthio-phosphonates and their methiodides with cholinesterases. Russ Chem Bull 24, 2459–2461 (1975). https://doi.org/10.1007/BF00921666

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  • DOI: https://doi.org/10.1007/BF00921666

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