New syntheses of pterin based on ethylenediamine and ethanolamine
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Pterin was obtained by heating 2,6-diamino-4-hydroxy-5-nitrosopyrimidine with ethanolamine in ethylene glycol, and it is also formed by reacting 2,6-diamino-4-hydroxypyrimidine with ethylenediamine in ethylene glycol in the presence of cupric acetate and subsequent oxidation with alkaline hydrogen peroxide.
When 2,6-diamino-4-hydroxypyrimidine is reacted with benzylamine or ethanolamine in ethylene glycol in the presence of cupric acetate it, respectively, gives 6-benzylamino- or 6-(β-hydroxyethylamino)-2-amino-4-hydroxypyrimidine.
KeywordsOxidation Hydrogen Acetate Ethylene Hydrogen Peroxide
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