New syntheses of pterin based on ethylenediamine and ethanolamine

  • S. I. Zav'yalov
  • L. F. Ovechkina
Brief Communications
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Conclusions

  1. 1.

    Pterin was obtained by heating 2,6-diamino-4-hydroxy-5-nitrosopyrimidine with ethanolamine in ethylene glycol, and it is also formed by reacting 2,6-diamino-4-hydroxypyrimidine with ethylenediamine in ethylene glycol in the presence of cupric acetate and subsequent oxidation with alkaline hydrogen peroxide.

     
  2. 2.

    When 2,6-diamino-4-hydroxypyrimidine is reacted with benzylamine or ethanolamine in ethylene glycol in the presence of cupric acetate it, respectively, gives 6-benzylamino- or 6-(β-hydroxyethylamino)-2-amino-4-hydroxypyrimidine.

     

Keywords

Oxidation Hydrogen Acetate Ethylene Hydrogen Peroxide 

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Literature cited

  1. 1.
    S. I. Zav'yalov, T. K. Budkova, and N. I. Aronova, Izv. Akad. Nauk SSSR, Ser. Khim.,1973, 2136.Google Scholar
  2. 2.
    G. B. Elion and G. H. Hitchings, J. Am. Chem. Soc.,74, 3847 (1952).Google Scholar
  3. 3.
    C. W. Noell and R. K. Robins, J. Med. Pharm. Chem.,5, 559 (1962).Google Scholar
  4. 4.
    G. B. Elion and G. H. Hitchings, J. Am. Chem. Soc.,75, 4311 (1953).Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • S. I. Zav'yalov
    • 1
  • L. F. Ovechkina
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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