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Synthesis of inhibitor of acid proteinases on macroporous silica gel as the inorganic support

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    An inhibitor of acid proteinases was synthesized, which was immobilized on silanized Silochrome.

  2. 2.

    It was shown that the nonspecific adsorption of proteins on silanized Silochrome in acid medium is reversible.

  3. 3.

    It was verified that the inhibitor diazoacetylnorleucine, which is attached to the silanized Silochrome, is capable of irreversibly binding pepsin in acid medium and cleaving it in alkaline medium.

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Author information

Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    V. V. Kiseleva, E. D. Kaverzneva & V. M. Silina

Authors
  1. V. V. Kiseleva
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  2. E. D. Kaverzneva
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  3. V. M. Silina
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4,pp. 930–933, April, 1975.

The authors express their gratitude to S. P. Zhdanov and E. V. Koromal'di for the porous glass sample, to A. V. Kiselev, Yu. S. Nikitin, and T. D. Khokhlova for the Silochrome sample and consultation on its use, and to I. P. Yakovlev for taking the IR spectra.

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Kiseleva, V.V., Kaverzneva, E.D. & Silina, V.M. Synthesis of inhibitor of acid proteinases on macroporous silica gel as the inorganic support. Russ Chem Bull 24, 844–846 (1975). https://doi.org/10.1007/BF00920707

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  • DOI: https://doi.org/10.1007/BF00920707

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