Journal of Neurology

, Volume 241, Issue 10, pp 624–627 | Cite as

Re-evaluation of classic senile plaques by three-dimensional analysis

  • Takemi Kimura
  • Toshiyuki Hisano
  • Hiroyuki Yoshida
  • Keishi Ueda
  • Taihei Miyakawa
Original Communication


We evaluated the proportion of classic plaques among all of the senile plaques in four Alzheimer brains (frontal, temporal, occipital and hippocampal areas) by the usual method of two-dimensional analysis using a single methenamine silver-stained section and three-dimensional analysis using a set of serial sections. Three-dimensional analysis showed the number and percentage of classic plaques to be 2–5 times greater than those revealed by two-dimensional analysis. In the hippocampal area of one case, no classic plaques were found by two-dimensional analysis but three-dimensional analysis showed that some classic plaques were present. From these findings, it is suggested that three-dimensional analysis using serial sections is indispensable for sub-classifying senile plaques.

Key words

Senile plaques Classic plaques Classification Three-dimensional analysis Alzheimer's disease 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Takemi Kimura
    • 1
  • Toshiyuki Hisano
    • 1
  • Hiroyuki Yoshida
    • 1
  • Keishi Ueda
    • 1
  • Taihei Miyakawa
    • 2
  1. 1.Division of Clinical ResearchNational Kikuchi Hospital for Mental and Nervous DiseasesKikuchi-gun, KumamotoJapan
  2. 2.Department of NeuropsychiatryKumamoto University Medical SchoolKumamotoJapan

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