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Osmotic state of lenses in three dominant murine cataract mutants

  • Jochen Graw
  • Peter Reitmeir
  • Andrea Wulff
Laboratory Investigations

Abstract

Three newly detected dominant cataract mutations (Asc-1, Cat-3vao,Tcm) were investigated for effects on osmotic alterations in the lenses of heterozygotes. The lens wet weight was reduced in two mutant lines (Cat-3vao andTcm), and the water content in the lenses of theCat-3vao mice was increased. Moreover, in the cataractous lenses fromCat-3vao mice, the sodium-potassium-adenosine triphosphatase (Na+ -K+-ATPase) activity was enhanced and the ATP concentration, correspondingly decreased. The osmotic variations observed in theCat-3vao mutants might have been due to a metabolic response to the yet unknown, primary pathological event. The lenses of the other two mutant lines (Asc-1 andTcm) revealed no alterations that could be related to osmotic stress. In no mutant line investigated could a decrease in Na+-K+-ATPase activity be demonstrated that was similar to the causative factor in the Nakano mutant line. TheCat-3vao mice exhibited some similarities to the Philly mutant line.

Keywords

Public Health Cataract ATPase Activity Osmotic Stress Causative Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Jochen Graw
    • 1
  • Peter Reitmeir
    • 2
  • Andrea Wulff
    • 2
  1. 1.GSF-Institut für SäugetiergenetikNeuherbergGermany
  2. 2.GSF-Institut für Medizinische Informatik und SystemforschungNeuherbergGermany

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