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Journal of Clinical Immunology

, Volume 13, Issue 6, pp 381–388 | Cite as

B cell activation and human immunodeficiency virus infection. V. Phenotypic and functional alterations in CD5+ and CD5 B cell subsets

  • Stefano Indraccolo
  • Marta Mion
  • Rita Zamarchi
  • Arianna Veronesi
  • Maria Luisa Veronese
  • Marina Panozzo
  • Corrado Betterle
  • Andrea Barelli
  • Alfredo Borri
  • Alberto Amadori
  • Luigi Chieco-Bianchi
Original Articles

Abstract

B cell dysregulation is a hallmark of human immunodeficiency virus infection. Since B lymphocytes comprise two distinct subpopulations, CD5+ and CD5 cells, we addressed their individual phenotypic and functional behavior. Seropositive patients with both limited and advanced disease progression had an increased percentage of peripheral blood CD5+ B cells, compared to seronegative controls (20.1±2.1 and 22.7±5.7, respectively, vs 17.0±3.4 in controls); however, due to the lymphopenia and reduced number of circulating B cells in infected individuals, the absolute number of CD19+ CD5+ lymphocytes was actually reduced. Although HIV-specific antibodies were synthesized spontaneouslyin vitro only by CD5 B cells, a 10-fold lower degree of spontaneous, non-HIV-specific activation was also displayed by unstimulated CD5+ B cells. These findings indicate that B cell dysregulation during HIV infection involves both the CD5 and the CD5+ B cell compartments; moreover, in view of the putative role of CD5+ B cells in autoimmune phenomena and IL-10 production, these data reinforce the possibility that B cell dysfunction might be causally involved in AIDS pathogenesis.

Key words

CD5 B lymphocytes AIDS human immunodeficiency virus (HIV) anti-HIV antibody 

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Stefano Indraccolo
    • 1
    • 2
  • Marta Mion
    • 1
  • Rita Zamarchi
    • 1
  • Arianna Veronesi
    • 1
  • Maria Luisa Veronese
    • 1
  • Marina Panozzo
    • 1
    • 2
  • Corrado Betterle
    • 3
  • Andrea Barelli
    • 4
  • Alfredo Borri
    • 4
  • Alberto Amadori
    • 1
  • Luigi Chieco-Bianchi
    • 1
  1. 1.Institute of Oncology, Interuniversity Center for Research on CanceUniversity of PadovaPadovaItaly
  2. 2.ST, Biotechnology SectionPadovaItaly
  3. 3.Institute of Semeiotica Medica, Chair of EndocrinologyUniversity of PadovaPadovaItaly
  4. 4.USSL 36, MestreVeniceItaly

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