, Volume 13, Issue 1, pp 47–58 | Cite as

Fluoride activation of neutrophils

Similarities to formylmethionyl-leucyl-phenylalanine
  • Walter L. Gabler
  • Howard R. Creamer
  • Wesley W. Bullock
Original Articles


Fluoride induced degranulation of both primary and specific granules from neutrophils pretreated with cytochalasin B. There was a similarity in the dependency on extracellular Ca2+ for fluoride- and for FMLP-stimulated O2 generation and degranulation. Pertussis toxin, but not cholera toxin, inhibited FMLP and fluoride activation of neutrophils, while neither toxin affected PMA activation of these cells. These results suggest that fluoride and FMLP activate neutrophils through a common Ca2+-dependent and pertussis toxin-sensitive pathway.


Public Health Internal Medicine Fluoride Pertussis Cholera 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Walter L. Gabler
    • 1
  • Howard R. Creamer
    • 2
  • Wesley W. Bullock
    • 2
  1. 1.Departments of BiochemistryOregon Health Sciences UniversityPortland
  2. 2.Oral Microbiology/ImmunologyOregon Health Sciences UniversityPortland

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