, Volume 16, Issue 2, pp 147–158 | Cite as

Modulation of neutrophil functions by activated platelet release factors

  • Susanna Spisani
  • Anna Lisa Giuliani
  • Teresa Cavalletti
  • Margherita Zaccarini
  • Laura Milani
  • Riccardo Gavioli
  • Serena Traniello
Original Articles


Platelets activated with physiological agonists, such as thrombin, ADP, or collagen, released products able to modulate neutrophil functions. In particular, platelet supernatant contained an inhibitor of superoxide anion generation induced by phorbol ester and a chemotactic factor for human neutrophils. The proteolytic digestion of platelet supernatant completely abrogated chemotactic activity without interfering with the inhibitory effect, indicating the presence of different molecules involved in the modulation of different neutrophil functions. This was further confirmed by the pretreatment of platelets with aromatic benzamidine which abolished chemotactic activity, but did not affect superoxide inhibition of neutrophils. This report provides evidence for interaction of platelets and inflammatory cells, suggesting that platelets are able to induce accumulation of neutrophils and control their respiratory burst, which also has a critical role in tissue damaging in inflammation.


Superoxide Thrombin Phorbol Human Neutrophil Phorbol Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Susanna Spisani
    • 1
  • Anna Lisa Giuliani
    • 1
  • Teresa Cavalletti
    • 1
  • Margherita Zaccarini
    • 1
  • Laura Milani
    • 1
  • Riccardo Gavioli
    • 1
  • Serena Traniello
    • 1
  1. 1.Instituto di Chimica BiologicaUniversità di FerraraFerraraItaly

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