Advertisement

Visibility of the normal retinal nerve fiber layer correlated with rim width and vessel caliber

  • Jost B. Jonas
  • Dennis Schiro
Clinical investigations

Abstract

Since the distribution of the retinal nerve fiber layer (RNFL) is not regular, this study was performed to evaluate the normal regional variation in its ophthalmoscopic appearance. Wide-angle red-free photographs of the RNFL and color stereo optic disc slides of 195 normal eyes of 119 subjects were morphometrically examined. The RNFL was most visible in the temporal inferior sector, with the neuroretinal rim being correspondingly broadest (P < 0.001) and the diameter of the corresponding retinal artery the widest; these parameters were found to diminish appreciably in the temporal superior sector, the nasal superior sector, and the nasal inferior sector in this order. The visibility of the RNFL in a particular region therefore correlates positively with the rim width and retinal artery caliber in that region, the RNFL being most detectable in the temporal inferior part of the fundus. This may be important in the evaluation of eyes with optic nerve damage.

Keywords

Public Health Color Optic Nerve Regional Variation Optic Disc 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Airaksinen PJ, Drance SM (1985) Neuroretinal rim area and retinal nerve fiber layer in glaucoma. Arch Ophthalmol 103:203–204Google Scholar
  2. 2.
    Airaksinen PJ, Mustonen E, Alanku HI (1981) Optic disc haemorrhages precede retinal nerve fibre layer defects in ocular hypertension. Acta Ophthalmol 59:627–641Google Scholar
  3. 3.
    Airaksinen PJ, Drance SM, Doublas GR, Mawson DK, Nieminen H (1984) Diffuse and localized nerve fiber loss in glaucoma. Am J Ophthalmol 98:566–571Google Scholar
  4. 4.
    Balazsi AG, Rootman J, Drance SM, Schulzer M, Douglas GR (1984) The effect of age on the nerve fiber population of the human optic nerve. Am J Ophthalmol 97:760–766Google Scholar
  5. 5.
    Dandona L, Quigley HA, Brown AE, Enger C (1990) Quantitative regional structure of the normal human lamina cribrosa. Arch Ophthalmol 108:393–398Google Scholar
  6. 6.
    Drance SM, Airaksinen PJ, Price M, Schulzer M, Douglas GR, Tansley BW (1986) The correlation of functional and structural measurements in glaucoma patients and normal subjects. Am J Ophthalmol 102:612–616Google Scholar
  7. 7.
    Hoyt WF, Schlicke B, Eckelhoff RJ (1972) Funduscopic appearance of a nerve fiber bundle defect. Br J Ophthalmol 56:577–583Google Scholar
  8. 8.
    Hoyt WF, Frisén L, Newman NM (1973) Funduscopy of nerve fiber layer defects in glaucoma. Invest Ophthalmol 12:814–829Google Scholar
  9. 9.
    Iwata K, Nanba K, Abe H (1982) Die beginnende Fundusveränderung infolge rezidivierender kleiner Krisen beim PosnerSchlosman-Syndrom — ein Modell für das Glaucoma chronicum simplex. Klin Monatsbl Augenheilkd 180:20–26Google Scholar
  10. 10.
    Jonas JB (1989) Biomorphometrie des Nervus opticus. (Bücherei des Augenarztes.) Enke, StuttgartGoogle Scholar
  11. 11.
    Jonas JB, Naumann GOH (1989) Parapapillary retinal vessel diameter in normal and glaucoma eyes. II. Correlations. Invest Ophthalmol Vis Sci 30:1604–1611Google Scholar
  12. 12.
    Jonas JB, Gusek GC, Naumann GOH (1988) Optic disc morphometry in chronic primary open-angle glaucoma. I. Morphometric intrapapillary characteristics. Graefe's Arch Clin Exp Ophthalmol 226:522–530Google Scholar
  13. 13.
    Jonas JB, Gusek GC, Naumann GOH (1988) Optic disc, cup, and neuroretinal rim size, configuration, and correlations in normal eyes. Invest Ophthalmol Vis Sci 29:1151–1158Google Scholar
  14. 14.
    Jonas JB, Nguyen NX, Naumann GOH (1989) The retinal nerve fiber layer in normal eyes. Ophthalmology 96:627–632Google Scholar
  15. 15.
    Jonas JB, Nguyen XN, Naumann GOH (1989) Parapapillary retinal vessel diameter in normal and glaucoma eyes. I. Morphometric data. Invest Ophthalmol Vis Sci 30:1599–1603Google Scholar
  16. 16.
    Jonas JB, Nguyen NX, Strahwald H, Naumann GOH (1989) Die retinale Nervenfaserschicht in Normal- und Glaukomaugen. I. Semiquantitative Daten von 398 Glaukomaugen. Klin Monatsbi Augenheilkd 194:437–446Google Scholar
  17. 17.
    Jonas JB, Müller-Bergh JA, Schlötzer-Schrehardt UM, Naumann GOH (1990) Histomorphometry of the human optic nerve. Invest Ophthalmol Vis Sci 31:736–744Google Scholar
  18. 18.
    Jonas JB, Fernández MC, Naumann GOH (1991) Parapapillary atrophy and retinal vessel caliber in nonglaucomatous optic nerve damage. Invest Ophthalmol Vis Sci 32:2942–2947Google Scholar
  19. 19.
    Jonas JB, Mardin CY, Schlötzer-Schrehardt U, Naumann GOH (1991) Histomorphometry of the human lamina cribrosa surface. Invest Opthhalmol Vis Sci 32:401–405Google Scholar
  20. 20.
    Jonas JB, Schmidt AM, Müller-Bergh JA, Schlötzer-Schrehardt UM, Naumann GOH (1992) Human optic nerve fiber count and optic disc size. Invest Opthalmol Vis Sci 33:2012–2018Google Scholar
  21. 21.
    Littmann H (1982) Zur Bestimmung der wahren Größe eines Objektes auf dem Hintergrund des lebenden Auges. Klin Monatsbi Augenheilkd 180:286–289Google Scholar
  22. 22.
    Quigley HA, Addicks EM (1982) Quantitative studies of retinal nerve fiber layer defects. Arch Ophthalmol 100:807–814Google Scholar
  23. 23.
    Quigley HA, Davis EB, Anderson DR (1977) Descending optic nerve degeneration in primates. Invest Ophthalmol Vis Sci 16:841–849Google Scholar
  24. 24.
    Quigley HA, Miller NR, George T (1980) Clinical evaluation of nerve fiber atrophy as indicator of glaucomatous optic nerve damage. Arch Ophthalmol 98:1564–1571Google Scholar
  25. 25.
    Quigley HA, Colemann AL, Dormann-Pease ME (1991) Larger optic nerve heads have more nerve fibers in normal monkey eyes. Arch Ophthalmol 109:1441–1443Google Scholar
  26. 26.
    Radius RL (1980) Thickness of the retinal nerve fiber layer in primate eyes. Arch Opthalmol 98:1625–1629Google Scholar
  27. 27.
    Sommer A, Miller NR, Pollack I, Maumence AE, George T (1977) The nerve fiber layer in the diagnosis of glaucoma. Arch Ophthalmol 95:2149–2156Google Scholar
  28. 28.
    Sommer A, Quigley HA, Robin AL, Miller NR, Katz J, Arkell S (1984) Evaluation of nerve fiber layer assessment. Arch Ophthalmol 102:1766–1771Google Scholar
  29. 29.
    Sommer A, Katz J, Quigley HA, Miller NR, Robin AL, Richter RC, Witt KA (1991) Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 109:77–83Google Scholar
  30. 30.
    Vogt A (1913) Herstellung eines gelbblauen Lichtfiltrates, in welchem die Makula centralis in vivo in gelber Farbe erscheint, die Nervenfasern der Netzhaut und andere feine Einzelheiten derselben sichtbar werden und der Grad der Gelbfärbung der Linse ophthalmoskopisch nachweisbar ist. Graefe's Arch Clin Exp Ophthalmol 84:293–311Google Scholar
  31. 31.
    Vogt A (1917) Die Nervenfaserstreifung der menschlichen Netzhaut mit besonderer Berücksichtigung der Differential-Diagnose gegenüber pathologischen streifenförmigen Reflexen (präretinalen Fältelungen). Klin Monatsbi Augenheilkd 58:399–411Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Jost B. Jonas
    • 1
  • Dennis Schiro
    • 1
  1. 1.Augenklinik der Universität ErlangenErlangenGermany

Personalised recommendations