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Progressive change in lymphocyte distribution and degree of hypergammaglobulinemia with age in children with hemophilia

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Abstract

Fifty asymptomatic, pediatric hemophiliacs were examined for distribution of T-cell subsets, responsiveness to mitogen stimulation, interleukin-2 production, hypergammaglobulinemia, and the presence of antibody to virus including the human T-lymphotrophic virus type III (HTLV-III). Hemophilia A patients receiving factor VIII concentrate as replacement therapy had the most pronounced changes including decreased T4/T8 ratios and lowerin vitro responsiveness to both phytohemagglutinin and pokeweed mitogen. Hemophilia A patients treated with cryoprecipitate and hemophilia B patients did not demonstrate these changes. Regardless of replacement therapy, hemophiliacs demonstrated a progressive decrease in the T4/T8 ratio and a progressive increase in the degree of IgG hypergammaglobulinemia as they aged. The amount of factor or cryoprecipitate or exposure to virus did not influence the T4/T8 ratio. These changes appear to be a result of chronic product exposure, which becomes more pronounced with increasing age.

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Authors and Affiliations

  1. Departments of Pediatrics and Pathology, Ohio State University School of Medicine, Children's Hospital, 43205, Columbus, Ohio

    B. T. Shannon

  2. Department of Pediatrics, Ohio State University School of Medicine, Children's Hospital, 43205, Columbus, Ohio

    J. Roach, M. Cheek-luten & F. B. Ruymann

  3. Department of Surgery, Ohio State University School of Medicine, 43210, Columbus, Ohio

    C. Orosz

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  1. B. T. Shannon
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  2. J. Roach
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  3. M. Cheek-luten
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  4. C. Orosz
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Shannon, B.T., Roach, J., Cheek-luten, M. et al. Progressive change in lymphocyte distribution and degree of hypergammaglobulinemia with age in children with hemophilia. J Clin Immunol 6, 121–129 (1986). https://doi.org/10.1007/BF00918744

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