Journal of Clinical Immunology

, Volume 9, Issue 4, pp 279–286 | Cite as

Immunoglobulin levels in saliva in individuals with selective IgA deficiency: Compensatory IgM secretion and its correlation with HLA and susceptibility to infections

  • G. Norhagen E.
  • P. E. Engström
  • L. Hammarström
  • P. Ö. Söder
  • C. I. E. Smith
Original Articles


Total levels of IgA, IgM, and IgG were measured in unstimulated whole saliva and serum from 63 individuals with selective IgA deficiency. Values were compared with the incidence of upper respiratory tract infections, antibiotic treatments (necessitated by upper respiratory tract infections), and HLA antigens. A statistically significant increase in salivary IgM and IgG levels was noted in individuals with selective IgA deficiency compared to healthy normal individuals. Healthy individuals with selective IgA deficiency did not have increased concentrations of salivary IgM compared to infectious-prone patients. Nor was there any correlation found between proneness to infections and HLA antigens or between salivary IgM or IgG levels and HLA antigens in this patient material.

Key words

IgA deficiency saliva antibodies HLA infections 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • G. Norhagen E.
    • 1
    • 2
  • P. E. Engström
    • 1
    • 2
  • L. Hammarström
    • 1
    • 3
  • P. Ö. Söder
    • 2
  • C. I. E. Smith
    • 1
    • 3
  1. 1.Department of Clinical Immunology, Karolinska InstituteHuddinge HospitalStockholmSweden
  2. 2.Department of Periodontology, Karolinska InstituteHuddinge HospitalStockholmSweden
  3. 3.Department of Immunology, The Arrhenius Laboratories for Natural ScienceUniversity of StockholmStockholmSweden

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