, Volume 8, Issue 4, pp 417–427 | Cite as

Effect of amoxycillin and doxycycline on function of human granulocytes tested in vitro and on chemotaxis of granulocytes from rabbits given the two antibiotics

  • Vincent Grec
  • Philippe C. Frei
Original Articles


The effect of amoxycillin and doxycyciine on human granulocyte function was studied in vitro. The antimicrobial agents were added to tests of chemotaxis, random motility, yeast phagocytosis, and killing, at progressing concentrations. The effect was also evaluated in vivo by measuring chemotaxis and random motiiity (agarose technique) of granulocytes from rabbits injected with these antibiotics. Amoxycillin was shown to have a slightly stimulating effect on chemotaxis, demonstrable only at the highest concentration tested (100 μg/ml), and no effect on the other variables, Doxycyciine had a dose-related inhibitory effect on chemotaxis, random motiiity, and phagocytosis, and no effect on killing. Chemotaxis and random motiiity were slightly, but not significantly, stimulated in vivo when rabbits were given amoxycillin. Chemotaxis (but not random motiiity) was significantly impaired when the rabbits were given doxycyciine.


Public Health Internal Medicine Agarose Antimicrobial Agent Doxycycline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Vincent Grec
    • 1
  • Philippe C. Frei
    • 1
  1. 1.Division of Immunology and Allergy, Department of MedicineCentre Hospitalier Universitaire VaudoisLausanneSwitzerland

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