Inflammation

, Volume 8, Issue 4, pp 337–342 | Cite as

Direct modification of plasma low-density lipoproteins in interstitial inflammatory fluid of the rabbit

  • Thomas L. Raymond
  • Scott A. Reynolds
Original Articles

Abstract

Utilizing the polyvinyl sponge-implant model in the rabbit, we have previously demonstrated modification in low-density lipoproteins (LDL) in the extravascular space in association with a cellular inflammatory response. In an attempt to isolate the source of these modifications, plasma LDL was labeled with125I, and introduced directly into the extravascular space at the time of sponge implantation. [125I] plasma LDL recovered from interstitial inflammatory fluid (IF) at 24 h after implantation demonstrated increased electrophoretic mobility as well as heterogeneity in particle size and hydrated density. These results are in agreement with our previous observations and indicate that modification in IF-LDL probably occurs after it has entered the extravascular space across the vascular wall.

Keywords

Public Health Internal Medicine Hydrated Inflammatory Response Particle Size 

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Thomas L. Raymond
    • 1
  • Scott A. Reynolds
    • 1
  1. 1.Department of Internal MedicineEast Tennessee State UniversityJohnson City

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