Skip to main content
Log in

Some copper coordination compounds and their antiinflammatory and antiulcer activities

  • Published:
Inflammation Aims and scope Submit manuscript


The anti-inflammatory and antiulcer activities of some copper complexes are presented. Data are provided to show that copper complexes of the clinically used antiarthritic drugs are more potent as antiinflammatory agents, less toxic than the parent compounds, and have potent antiulcer activity. Mechanistic aspects of their biological activities are also discussed in support of their clinical utility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Sorenson, J.R.J. 1974. Copper chelates as possible active metabolites of anti-inflammatory agents. 167th Nat. Meeting, Am. Chem. Soc., Med. Chem. Division, Abstract No. 73.

  2. Sorenson, J.R.J. 1974. The anti-inflammatory activity of some copper chelates. Trace substances.In Environmental Health—VII. A Symposium. D.D. Hemphill, editor. University of Missouri, Columbia, pp. 305–311.

    Google Scholar 

  3. Sorenson, J.R.J. 1976. Copper chelates as possible active forms of the anti-arthritic agents.J. Med. Chem. 19:135.

    Google Scholar 

  4. Winter, C.A., E.A. Risley, andG.W. Nuss. 1963. Anti-inflammatory and antipyretic activities of indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid.J. Pharmacol Exp Ther. 141:369.

    Google Scholar 

  5. White, C. 1952. The use of ranks in a test of significance for comparing two treatments.Biometrics 8:33.

    Google Scholar 

  6. Meir, R., W. Schuler, andP. Desaulles. 1950. Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch Cortisone. Experientia6:469.

    Google Scholar 

  7. Aspinall, R.L., andP.S. Cammarata. 1969. Effect of prostaglandin E2 on adjuvant arthritis.Nature London 224:1320.

    Google Scholar 

  8. Miller, L.C., andM.L. Tainter. 1944. Estimation of the ED50 and its error by means of logarithmic-Probitgraph paper.Proc. Soc. Exp. Biol. Med. 57:261.

    Google Scholar 

  9. Shay, H., S.A. Komarov, S.S. Fels, D. Meranze, M. Gruenstein, andH. Siplet. 1945. A simple method for the uniform production of gastric ulceration in the rat.Gastroenterology 5:43.

    Google Scholar 

  10. Sorenson, J.R.J. 1975. Structure-activity relationships of some anti-inflammatory and anti-ulcer copper chelates. 168th Nat. Meeting, Am. Chem. Soc., Med. Chem. Division, Abstract No. 32.

  11. Townsend, S.F. 1961. Regeneration of gastric mucosa in rats.Am. J. Anat. 109:133.

    Google Scholar 

  12. Townsend, S.F. Personal communication.

  13. Lee, R.E., andW.E.M. Lands. 1972. Cofactors in the biosynthesis of prostaglandins F and F.Biochim. Biophys. Acta. 260:203.

    Google Scholar 

  14. Maddox, I.S. 1973. The role of copper in prostaglandin synthesis.Biochim. Biophys. Acta. 306:74.

    Google Scholar 

  15. McCord, J.M. 1974. Free radicals and inflammation: Protection of synovial fluid by superoxide dismutase.Science 185:529.

    Google Scholar 

  16. Fridovich, I. 1975. Superoxide dismutases.Ann. Rev. Biochem. 44:147.

    Google Scholar 

  17. Brigelius, R., R. Spottl, W. Bors, E. Lengfelder, M. Saran, andU. Weser. 1974. Superoxide dismutase activity of low molecular weight Cu. chelates studied by pulse radiolysis.FEBS Lett. 47:72.

    Google Scholar 

  18. Paschen, W., andU. Weser. 1975. Problems concerning the biochemical action of superoxide dismutase (erythrocuprein).Hoppe-Seyler's Z. Physiol. Chem. 356:727.

    Google Scholar 

  19. Brigelius, R., H.-J. Hartmann, W. Bors, M. Saran, E. Lengfelder, andU. Weser. 1975. Superoxide dismutase of Cu(tyr)2 and Cu, Co-erythrocuprein.Hoppe-Seyler's Z. Physiol. Chem. 356:739.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Sorenson, J.R.J. Some copper coordination compounds and their antiinflammatory and antiulcer activities. Inflammation 1, 317–331 (1976).

Download citation

  • Issue Date:

  • DOI: