Inflammation

, Volume 2, Issue 3, pp 191–197 | Cite as

Metabolism of arachidonic acid in rabbit alveolar macrophages

  • Saura Sahu
  • William S. Lynn
Article

Abstract

Rabbit alveolar macrophages incorporated radioactive arachidonic acid primarily into phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and triglycerides. When these cells, so labelled, were washed and treated with polystyrene beads, there was a distinct and reproducible decrease in the radioactivity of phosphatidylcholine, phosphatidylethanolamine, and triglyceerides. This decrease was accounted for by the appearance of two major prostaglandins, PGE2 and PGF2a, and uncharacterized hydroxy fatty acids, which may be 12-hydroxy-5,8,10,14-eicosatetraenoic acid, 5-hydroxy-6,8,11, 14-eicosatetraenoic acid, and/or 8-hydroxy-9,11,14-eicosatrienoic acid.

Keywords

Public Health Internal Medicine Triglyceride Prostaglandin Polystyrene 

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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Saura Sahu
    • 1
  • William S. Lynn
    • 1
  1. 1.Departments of Biochemistry and MedicineDuke University Medical CenterDurham

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