Journal of Clinical Immunology

, Volume 6, Issue 4, pp 273–283 | Cite as

Control of IgE synthesis in man

  • Donald Y. M. Leung
  • Raif S. Geha
Special Article

Key words

Fc receptor for IgE IgE IgE binding factor T lymphocytes regulation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ishizaka T, Ishizaka K: Activation of mast cells for mediator release through IgE receptors. Prog Allergy 34:188, 1984Google Scholar
  2. 2.
    Gonzalez-Molina A, Spiegelberg HL: A subpopulation of normal human peripheral B lymphocytes that bind IgE. J Clin Invest 59:616, 1977Google Scholar
  3. 3.
    Yodoi J, Ishizaka K: Lymphocytes bearing Fc receptors for IgE. 1. Presence of human and rat lymphocytes with Fc receptors. J Immunol 122:2577, 1979Google Scholar
  4. 4.
    Boltz-Nitulescu G, Plummer JM, Spiegelberg HL: Fc receptors for IgE on mouse macrophages and macrophage-like cell lines. J Immunol 128:2265, 1982Google Scholar
  5. 5.
    Melewicz FM, Plummer JM, Spiegelberg HL: Comparison of the Fc receptors for IgE on human lymphocytes and monocytes. J Immunol 129:563, 1982Google Scholar
  6. 6.
    Melewicz FM, Zeiger RS, Mellon MH, O'Connor RD, Spiegelberg HL: Increased peripheral blood monocytes with Fc receptors for IgE in patients with severe allergic disorders. J Immunol 126:1592, 1981Google Scholar
  7. 7.
    Ishizaka K: IgE-binding factors from rat T lymphocytes. Lymphokines 8:41, 1983Google Scholar
  8. 8.
    Plaut M, Liu MC, Conrad DH, Proud D, MacGlashan DW Jr, Kagey-Sobotka A, Lichenstein LM: Histamine release from human basophils is induced by IgE binding factors derived from human lung macrophages and an Fc receptor positive human B cell line. Clin Res 33:59A, 1985Google Scholar
  9. 9.
    Rouzer CA, Scott WA, Hamill AL, Liu FT, Katz DH, Cohn ZA: IgE immune complexes stimulate arachidonic acid release by mouse peritoneal macrophages. Proc Natl Acad Sci 79:5656, 1982Google Scholar
  10. 10.
    Rankin JA, Hitchcock M, Merrill W, Bach MK, Brashler JR, Askenase PW: IgE-dependent release of leukotriene C4 from alveolar macrophages. Nature 297:329, 1982Google Scholar
  11. 11.
    Rasmussen JE: Recent developments in the management of patients with atopic dermatitis. J Allergy Clin Immunol 74:771, 1985Google Scholar
  12. 12.
    Okumura K, Tada T: Regulation of homocytotropic antibody formation in the rat. III. Effect of thymectomy and splendectomy. J Immunol 106:1019, 1971Google Scholar
  13. 13.
    Tada T, Taniguchi M, Okumura K: Regulation of homocytotropic antibody formation in the rat. II. Effect of X irradiation. J Immunol 106:1012, 1971Google Scholar
  14. 14.
    Taniguchi M, Tada T: Regulation of homocytotropic antibody formation in the rat. IV. Effects of various immunosuppressive drugs. J Immunol 107:579, 1971Google Scholar
  15. 15.
    Buckley RH, Fiscus SA: Serum IgD and IgE concentration in immunodeficiency diseases. J Clin Invest 55:157, 1975Google Scholar
  16. 16.
    Geha RS, Reinherz EL, Leung D, McKee KT, Schlossman SF, Rosen FS: Deficiency of suppressor T cells in the hyperimmunoglobulinemia E syndrome. J Clin Invest 68:783, 1981Google Scholar
  17. 17.
    Leung DYM, Rhodes AR, Geha RS: Enumeration of T cell subsets in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol 67:450, 1981Google Scholar
  18. 18.
    Butler M, Atherton D, Levinsky RJ: Quantitative and functional deficit of suppressor T cells in children with atopic eczema. Clin Exp Immunol 50:92, 1982Google Scholar
  19. 19.
    Willemze R, DeGraaff-Reitsma CB, Crossen J, Van Vloten WA, Meijer CJL: Characterization of T cell subpopulations in skin and peripheral blood of patients with cutaneous T cell lymphomas and benign inflammatory dermatoses. J Invest Dermatol 80:60, 1983Google Scholar
  20. 20.
    Cooper KD, Wuepper KD, Hanifin JM: T cell subset enumeration and functional analysis in atopic dermatitis. Clin Res 28:566, 1980Google Scholar
  21. 21.
    Geha RS, Twarog F, Rappaport J, Parkman R, Rosen FS: Increased serum IgE levels following allogeneic bone marrow transplantation. J Allergy Clin Immunol 66:78, 1980Google Scholar
  22. 22.
    Reinherz EL, Parkman R, Rappaport J, Rosen FS, Schlossman SF: Aberrations of suppressor T cells in human graft versus host disease. N Engl J Med 300:1061, 1979Google Scholar
  23. 23.
    Spiegelberg HA, Plummer JM, Ruedi J, Thompson LF, Mellon MH, Zeiger RS: Lack of pokeweed mitogen-induced IgE formationin vitro by human peripheral blood mononuclear cells: detection of cross-reacting idiotypic determinants on polyclonal Ig by antibodies to a single IgE myeloma protein. J Immunol 131:3001, 1983Google Scholar
  24. 24.
    Saryan JA, Leung DYM, Geha RS: Induction of human IgE synthesis by a factor derived from T cells of patients with hyper IgE states. J Immunol 130:242, 1983Google Scholar
  25. 25.
    Fiser PM, Buckley RH: Human IgE biosynthesisin vitro: studies with atopic and normal blood mononuclear cells and subpopulations. J Immunol 123:1788, 1979Google Scholar
  26. 26.
    Saxon A, Morrow L, Steven RH: Subpopulations of circulating B cells and regulation T cells involved inin vitro immunoglobulin E production in atopic patients with elevated serum immunoglobulin E. J Clin Invest 65:1457, 1980Google Scholar
  27. 27.
    Romagnani S, Del Prete GF, Maggi E, Troncone R, Giudizi MG, Almerigogna F, Ricci M:In vitro production of IgE by human peripheral blood mononuclear cells. Clin Exp Immunol 42:579, 1980Google Scholar
  28. 28.
    Hemady Z, Blomberg F, Gellis S, Rocklin RE: IgE productionin vitro by human blood mononuclear cells: a comparison between atopic and non-atopic subjects. J Allergy Clin Immunol 71:324, 1983Google Scholar
  29. 29.
    Tijo AM, Hull WM, Gleich GL: Production of human immunoglobulin E antibodyin vitro. J Immunol 122:2131, 1979Google Scholar
  30. 30.
    Romagnani S, Maggi E, Del Prete GF, Almerigogna F, Biagiotti R, Guidizi MG, Ricci M:In vitro production of IgE by human peripheral blood mononuclear cells. IV. Modulation by allergen of the spontaneous IgE antibody biosynthesis. Clin Exp Immunol 49:185, 1982Google Scholar
  31. 31.
    Sampson HA, Buckley RH: Human IgE synthesisin vitro: A reassessment. J Immunol 127:829, 1981Google Scholar
  32. 32.
    Turner KJ, Holt PG, Holt BJ, Cameron KJ:In vitro synthesis of IgE by human peripheral blood leukocytes. III. Release of preformed antibody. Clin Exp Immunol 51:387, 1983Google Scholar
  33. 33.
    Zuraw BL, Nonaka M, O'Hair C, Katz DH: Human IgE antibody synthesisin vitro: stimulation of IgE responses by pokeweed mitogen and selective inhibition of such responses by human suppressive factor of allergy (SFA). J Immunol 127:1169, 1981Google Scholar
  34. 34.
    Saryan JA, Rappaport J, Leung DYM, Parkman R, Geha RS: Regulation of human IgE synthesis in acute graft vs host disease. J Clin Invest 71:556, 1983Google Scholar
  35. 35.
    Romagnani S, Maggi E, Del Prete GF, Ricci M: IgE synthesisin vitro induced by T cell factors from patients with elevated serum IgE levels. Clin Exp Immunol 52:85, 1983Google Scholar
  36. 36.
    Howard M, Paul WE: Regulation of B-cell growth and differentiation by soluble factors. Annu Rev Immunol 1:307, 1983Google Scholar
  37. 37.
    Lanzavecchia A: One out of five peripheral blood lymphocytes is activated to high-rate Ig production by human alloreactive T cell clones. Eur J Immunol 13:820, 1984Google Scholar
  38. 38.
    Umetsu DT, Leung DYM, Siraganian R, Jabara HH, Geha RS: Differential requirements of B cells from normal and allergic subjects for the induction of IgE synthesis by an alloreactive T cell clone. J Exp Med 162:202, 1985Google Scholar
  39. 39.
    Principato MA, Thompson GS, Friedman SM: A cloned major histocompatibility complex-restricted trinitrophenyl-reactive human T cell line that activates B cell subsets via two distinct pathways. J Exp Med 158:1444, 1983Google Scholar
  40. 40.
    Julius MH, von Boehmer H, Sidman CL: Dissociation of two signals required for activation of resting B cells. Proc Natl Acad Sci 79:1989, 1982Google Scholar
  41. 41.
    Mayer L, Posnett DN, Kunkel HG: Human malignant T cells capable of inducing an immunoglobulin class switch. J Exp Med 161:134, 1985Google Scholar
  42. 42.
    Kawanishi HL, Slatzman E, Strober W: Characteristics and regulatory function of murine Con A-induced cloned T cells obtained from Peyer's patches and spleen: Mechanisms regulating isotype-specific immunoglobulin production by Peyer's patch B cells. J Immunol 129:475, 1982Google Scholar
  43. 43.
    Glimcher LH, Shevach EM: Production of autoreactive I-region restricted T cell hybridomas. J Exp Med 156:640, 1982Google Scholar
  44. 44.
    Leung DYM, Young MC, Geha RS: Induction of IgG and IgE synthesis in normal B cells by autoreactive T cell clones. J Immunol 136:2851, 1986Google Scholar
  45. 45.
    Leung DYM, Siegel RL, Grady S, Krensky A, Meade R, Reinherz EL, Geha RS: Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol 23:100, 1982Google Scholar
  46. 46.
    Blaese RM, Grayson J, Steinberg AD: Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythematosus. Am J Med 69:345, 1980Google Scholar
  47. 47.
    Kusakawa S, Heiner DC: Elevated immunoglobulin E in the acute febrile mucocutaneous lymph node syndrome. Prediat Res 10:108, 1976Google Scholar
  48. 48.
    Rebhun J, Quismono F, Dubois E, Heiner DC: Systemic lupus erythematosus activity and IgE. Ann Allergy 50:34, 1983Google Scholar
  49. 49.
    Hemady Z, Gellis S, Chambers M, Rocklin RE: Abnormal regulation ofin vitro IgE synthesis by T cells obtained from patients with atopic dermatitis. Clin Immunol Immunopathol 35:156, 1985Google Scholar
  50. 50.
    Suemura M, Ishizaka K: Potentiation of IgE responsein vitro by T cells from rats infected withNippostrongylus brasiliensis. J Immunol 123:918, 1979Google Scholar
  51. 51.
    Hirashima M, Yodoi J, Ishizaka K: Regulatory role of IgE-binding factors from rat T lymphocytes. III. IgE-specific suppressive factor with IgE-binding activity. J Immunol 125:1442, 1980Google Scholar
  52. 52.
    Yodoi J, Hirashima M, Ishizaka K: Regulatory role of IgE-binding factors from rat T lymphocytes. The carbohydrate moieties in IgE-potentiating factors and IgE-suppressive factors. J Immunol 128:289, 1982Google Scholar
  53. 53.
    Thompson LF, Mellon MH, Zeiger RS, Spiegelberg HL: Characterization with monoclonal antibodies of T lymphocytes bearing Fc receptors for IgE (T cells) in atopic patients. J Immunol 131:2772, 1983Google Scholar
  54. 54.
    Spiegelberg HL, O'Connor RD, Simons RA, Mathison DA: Lymphocytes with immunoglobulin E. Fc receptors in patients with atopic disorders. J Clin Invest 64:714, 1979Google Scholar
  55. 55.
    Yodoi J, Ishizaka K: Lymphocytes bearing Fc receptors for IgE. I. Presence of human and rat T lymphocytes with Fc receptors. J Immunol 122:2577, 1979Google Scholar
  56. 56.
    Yodoi J, Ishizaka K: Induction of Fc-receptor bearing cellsin vitro in human peripheral lymphocytes. J Immunol 126:1692, 1981Google Scholar
  57. 57.
    Ishizaka K, Sandberg K: Formation of IgE binding factors by human T lymphocytes. J Immunol 126:1692, 1981Google Scholar
  58. 58.
    Young MC, Leung DYM, Geha RS: Production of IgE potentiating factor in man by T cell lines bearing Fc receptors for IgE. Eur J Immunol 14:871, 1984Google Scholar
  59. 59.
    Young MC, Geha RS, Maksad KN, Leung DYM: Characterization of human T cell derived IgE potentiating factor. Eur J Immunol (in press), 1986Google Scholar
  60. 60.
    Leung DYM, Frankel R, Brozek C, Geha RS: Potentiation of human IgE synthesis by plasma IgE binding factors from patients with the hyper IgE syndrome. J Clin Invest 77:952, 1986Google Scholar
  61. 61.
    Leung DYM, Brozek C, Frankel R, Geha RS: IgE specific suppressor factors in normal human serum. Clin Immunol Immunopathol 32:339, 1984Google Scholar
  62. 62.
    Ishizaka K: Twenty years with IgE: From the identification of IgE to regulatory factors for the IgE response. J Immunol 135:1, 1985Google Scholar
  63. 63.
    Yodoi J, Hirashima M, Bloom BR, Ishizaka K: Formation of IgE-binding factors by rat lymphocytes. I. Induction of IgE-binding factors by poly I:C and interferon. J Immunol 127:1579, 1981Google Scholar
  64. 64.
    Uede T, Sandberg K, Bloom BR, Ishizaka K: IgE-binding factors from mouse T lymphocytes. I. formation of IgE-binding factors by stimulation with homologous IgE and interferon. J Immunol 130:649, 1983Google Scholar
  65. 65.
    Hirashima M, Yodoi J, Ishizaka K: Formation of IgE-binding factors by rat T lymphocytes. II. Mechanisms of selective formation of IgE-potentiating factors by treatment with Bordetella pertussis vaccine. J Immunol 127:1804, 1981Google Scholar
  66. 66.
    Hirashima M, Yodoi J, Huff TF, Ishizaka K: Formation of IgE-binding factors by rat T lymphocytes. III. Mechanisms of selective formation of IgE-suppressive factors by treatment with complete Freund's adjuvant. J Immunol 127:1810, 1981Google Scholar
  67. 67.
    Uede T, Ishizaka K: Formation of IgE-binding factors by rat T lymphocytes. VI. Cellular mechanisms for the formation of IgE-potentiating factor and IgE-suppressive factor by antigenic stimulation of antigen-primed spleen cells. J Immunol 129:1391, 1982Google Scholar
  68. 68.
    Huff TF, Jardien P, Ishizaka K: Regulatory effects of human IgE-binding factors on the IgE response of rat lymphocytes. J Immunol 136:955, 1986Google Scholar
  69. 69.
    Leung DYM, Young MC, Wood N, Geha RS: Induction of IgE synthesis in normal human B cells: Sequential requirements for activation by an alloreactive T cell clone and IgE potentiating factor(s). J Exp Med (in press), 1986Google Scholar
  70. 70.
    Goldstein H, Volkman DJ, Ambrus JL, Fanei AS: Characterization of a T4+/Leu8+ T cell clone that directly helps B cell Ig production by secreting B cell differentiation factor. J Immunol 135:339, 1985Google Scholar
  71. 71.
    Coffman RL, Carty J: A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J Immunol 136:949, 1986Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Donald Y. M. Leung
    • 1
  • Raif S. Geha
    • 1
  1. 1.Division of Allergy, The Children's Hospital, Department of PediatricsHarvard Medical SchoolBoston

Personalised recommendations