Inflammation

, Volume 3, Issue 1, pp 81–86 | Cite as

Sympathetic or reflex footpad swelling due to crystal-induced inflammation in the opposite foot

  • Charles W. Denko
  • Mark Petricevic
Article

Abstract

Sympathetic or reflex footpad swelling occurred in rats when several crystals known to be pathogenic in human joints or soft tissues were injected into the opposite footpad. Monosodium urate (MSU), calcium pyrophosphate dihydrate (CaPPD), hydroxyapatite, calcium oxalate (CaOx), and xanthine (X) suspension induced varying degrees of such reflex or sympathetic swelling. In the second cycle of crystal-induced swelling, the foot that had been the initial or primary site of inflammation reacted with greater reflex swelling, when compared to the first cycle. Similarly, reflex increases in temperature occurred when CaPPD was injected. These reflex increases in swelling and temperature may relate to signs and symptoms of patients with reflex neurovascular dystrophy or shoulder-hand syndrome.

Keywords

Calcium Internal Medicine Soft Tissue Oxalate Hydroxyapatite 

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References

  1. 1.
    Steinbrocker, O. 1966. The painful shoulder.In Arthritis and Allied Conditions, 7th ed. J.L. Hollander, editor. Lea & Febiger, Philadelphia. pp. 1233–1274.Google Scholar
  2. 2.
    Denko, C.W., andM.W. Whitehouse. 1976. Experimental inflammation induced by naturally occurring microcrystalline calcium salts.J. Rheum. 3:54–62.Google Scholar
  3. 3.
    Steinbrocker, O., D. Neustadt, andS.J. Bosch. 1955. Painful shoulder syndromes-their diagnosis and treatment.Med. Clin. North Am. 33:563–585.Google Scholar
  4. 4.
    McCarty, D.J. 1974. Diagnostic mimicry in arthritis-patterns of joint involvement associated with calcium pyrophosphate dihydrate crystal deposits.Bull. Rheum. Dis. 25:804–809.Google Scholar
  5. 5.
    Wyngaarden, J.B. 1972. Xanthuria.In Metabolic Basis of Inherited Disease, 3rd ed. J.B. Stanbury, J.B. Wyngaarden, and D.S. Frederickson, editors. McGraw-Hill, New York. pp. 992–1002.Google Scholar
  6. 6.
    Denko, C.W. 1974. A phlogistic function of prostaglandin E1 in urate crystal inflammation.J. Rheum. 1:222–230.Google Scholar
  7. 7.
    Denko, C.W. 1972. A phlogistic function of PGE1 in calcium pyrophosphate dihydrate crystal-induced inflammation.J. Rheum. 2:251–257.Google Scholar
  8. 8.
    Denko, C.W., R.W. Moskowtiz, andG. Heinrich. 1972. Interrelated pharmacologic effects of prostaglandins and bradykinin.Pharmacology 8:353–360.Google Scholar
  9. 9.
    Hamamura, L., andJ. Garcia Leme. 1973. Neurogenic inflammation in the rat. Evidence for the release of a permeability factor from sensory nerves following electrical stimulation.Agents Actions 3:381–382.Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Charles W. Denko
    • 1
  • Mark Petricevic
    • 1
  1. 1.Case Western Reserve University and Scott Research LaboratoryFairview General HospitalCleveland

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