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Cells resistant to cytotoxic drugs are recognized by monoclonal antibody

Journal of Clinical Immunology volume 4, pages 403–411 (1984)Cite this article

Abstract

A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons. This molecule may be the P-glycoprotein previously associated with a drug-resistance permeability barrier (Riordan JR, Ling V: J Biol Chem 254: 12701–12705, 1979).

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Affiliations

  1. Ontario Cancer Institute, Division of Bioresearch, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    C. J. O'Hara

  2. McGill Cancer Centre, McGill University, and Division of Hematology, Royal Victoria Hospital, Montreal, Quebec, Canada

    J. Grover & G. B. Price

Authors
  1. C. J. O'Hara
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  2. J. Grover
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  3. G. B. Price
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O'Hara, C.J., Grover, J. & Price, G.B. Cells resistant to cytotoxic drugs are recognized by monoclonal antibody. J Clin Immunol 4, 403–411 (1984). https://doi.org/10.1007/BF00917144

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  • DOI: https://doi.org/10.1007/BF00917144

Key words

  • Hybridoma
  • vinca-alkaloids
  • antitumor
  • antibiotics
  • drug resistance