Journal of Clinical Immunology

, Volume 9, Issue 5, pp 369–377 | Cite as

Synthetic macrophages: Antigen presentation by liposomes bearing class II major histocompatibility complex (MHC) and membrane interleukin-1 (IL-1)

  • Ouahid Bakouche
  • Lawrence B. Lachman
Special Article

Key words

Interleukin-1 (IL-1) liposomes macrophages 


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  1. 1.
    Rosenthal AS, Shevach EM: Function of macrophages in antigen recognition by guinea pig T lymphocytes. J Exp Med 138:1194–1212, 1973Google Scholar
  2. 2.
    Ellner J, Lipsky PE, Rosenthal AS: Antigen handling by guinea pig macrophages: Further evidence for the sequestration of antigen relevant for activation of primed T lymphocytes. J Immunol 118:2053–2057, 1977Google Scholar
  3. 3.
    Weinberger O, Herrmann S, Mescher MF, Benacerraf B, Burakoff SJ: Antigen presenting cell function in induction of helper T cells for cytotoxic T-lymphocyte responses: Evidence for antigen processing. Proc. Natl. Acad. Sci. USA 78:1796–1799, 1981Google Scholar
  4. 4.
    Scala G, Oppenheim JJ: Antigen presentation by human monocytes: Evidence for stimulant processing and requirement for interleukin 1. J Immunol 131:1160–1166, 1983Google Scholar
  5. 5.
    Shimonkevitz R, Kappler J, Marrack P, Grey H: Antigen recognition by H-2 restricted cells. I. Cell-free antigen processing. J Exp Med 158:303–316, 1983Google Scholar
  6. 6.
    Allen PM, Beller DI, Braun J, Unanue, ER: The handling of Listeria monocytogenes by macrophages: The search for an immunogenic molecule in antigen presentation. J Immunol 132:323–331, 1984Google Scholar
  7. 7.
    Kaneoka H, Perez-Rojas G, Sasasuki T, Benike CJ, Engleman EG: Human T lymphocyte proliferation induced by a pan-T monoclonal antibody (anti-Leu4): heterogeneity of response is a function of monocytes. J Immunol 131:158–164, 1983Google Scholar
  8. 8.
    Abo T, Tilden AB, Balch CM, Kumagai K, Troup GM, Cooper MD: Ethnic differences in the lymphocyte proliferative response induced by a murine IgG1 antibody, Leu-4, to the T3 molecule. J Exp Med 160:303–309, 1984Google Scholar
  9. 9.
    Kurt-Jones EA, Virgin HW, Unanue ER: Relationship of macrophage Ia and membrane IL1 expression to antigen presentation. J Immunol 135:3652–3654, 1985Google Scholar
  10. 10.
    Yokota S, Geppert TD, Lipsky PE: Enhancement of antigen-and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-α. J Immunol 140:531–536, 1988Google Scholar
  11. 11.
    Brian AA, McConnell HM: Allogeneic stimualtion of cytotoxic T cells by supported planar membranes. Proc Natl Acad Sci USA 81:6159–6163, 1984Google Scholar
  12. 12.
    Burakoff SJ, Mescher HF: Reconstituted membranes and liposomes in the study of lymphocyte interactions.In Membrane Reconstitution, Cell Surface Reviews, Vol 8, G. Poste, GL Nicolson (eds). Amsterdam, Elsevier North-Holland, 1982, pp 291–298Google Scholar
  13. 13.
    Bakouche O, Gerlier D: Enhancement of immunogenicity of tumor virus antigen by liposomes: The effect of lipid composition. Immunology 58:507–513, 1986Google Scholar
  14. 14.
    Yasuda T, Dancey GF, Kinsky SC: Immunogenicity of liposomal membranes in mice: Dependence on phospholipid composition. Proc Natl Acad Sci USA 74:1234–1236, 1977Google Scholar
  15. 15.
    Sherman L, Burakoff SJ, Mescher MF: Induction of allogeneic cytolytic T lymphocytes by partially purified membrane gycoproteins. Cell Immunol 51:141–150, 1980Google Scholar
  16. 16.
    Rafael L, Tom BH. In vitro induction of primary and secondary xenoimmune responses by liposomes containing human colon tumor cell antigens. Cell Immunol 71:224–240, 1982Google Scholar
  17. 17.
    Gerlier D, Bakouche O, Dore JF: Liposomes as a tool to study the role of membrane presentation in the immunogenicity of a MuLV-related tumor antigen. J Immunol 131:485–490, 1983Google Scholar
  18. 18.
    Kinsky SC, Nicolotti RA: Immunological properties of model membranes. Annu Rev Biochem 46:49–67, 1977Google Scholar
  19. 19.
    Walden P, Nagy ZA, Klein J: Induction of regulatory T-lymphocyte responses by liposomes carrying major histocompatibility complex molecules and foreign antigen. Nature 315:327–329, 1985Google Scholar
  20. 20.
    Bakouche O, Brown DC, Lachman LB: Liposomes expressing IL1 biological activity. J Immunol 138:4256–4262, 1987Google Scholar
  21. 21.
    Buus S, Sette A, Colon SM, Jenis DM, Grey HM: Isolation and characterization of antigen-1a complexes involved in T cell recognition. Cell 47:1071–1077, 1986Google Scholar
  22. 22.
    Ellner JJ, Lipsky PE, Rosenthal AS: Antigen handling by guinea pig macrophages. Further evidence for the sequestration of antigen relevant for activation of printed T lymphocytes. J Immunol 118:2053–2057, 1977Google Scholar
  23. 23.
    Waldron JA, Hann RG, Rosenthal AS: Antigen-induced proliferation of guinea pig lymphocytes in vitro: Functional aspects of antigen handling by macrophages. J Immunol 112:746–755, 1974Google Scholar
  24. 24.
    Chesnut RW, Colon SM, Grey HM: Requirements for the processing of antigens by antigen-presenting B cells. I. Functional comparison of B cell tumors and macrophages. J Immunol 129:2382–2388, 1982Google Scholar
  25. 25.
    Yamashita U, Shevach EM: The syngeneic mixed lymphocyte reaction: The genetic requirement for the recognition of antigen in association with self. J Immunol 124:1773–1778, 1980Google Scholar
  26. 26.
    McKenzie IFC, Morgan GM, Sandrin MS, Michaelides MM, Melvold RW, Kohn HI: B6. C-H-2bm12. A new H-2 mutation in the I-region in the mouse. J Exp Med 150:1323–1338, 1979Google Scholar
  27. 27.
    Yano A, Schwartz RH, Paul WE: Antigen presentation of the murine T-lymphocyte proliferative response: I. Requirement for genetic identity at the major histocompatibility complex. J Exp Med 146:828–843, 1977Google Scholar
  28. 28.
    Mizel SB, Ben-Zvi A: Studies on the role of lymphocyte-activating factor (interleukin 1) in antigen-induced lymphocyte proliferation. Cell Immunol 54:382–389, 1980Google Scholar
  29. 29.
    Watts TH, Brian AA, Kappler JW, Marrack P, McConnell HM: Antigen presentation by supported planar membranes containing affinity-purified I-Ad. Proc Natl Acad Sci USA 81:7564–7568, 1984Google Scholar
  30. 30.
    Grey HM, Colon SM, Chesnut RW: Requirements for the processing of antigen by antigen-presenting B cells. II. Biochemical comparison of the fate of antigen in B cell tumors and macrophages. J Immunol 129:2389–2395, 1982Google Scholar
  31. 31.
    Ziegler K, Unanue ER: Identification of a macrophage antigen-processing event required for la region-restricted antigen presentation to T lymphocytes. J Immunol 127:1869–1875, 1981Google Scholar
  32. 32.
    Benacerraf B: A hypothesis to relate the specificity of T lymphocytes and the activity of I-region-specific lr genes in macrophages and B lymphocytes. J Immunol 120:1809–1812, 1978Google Scholar
  33. 33.
    Chesnut R, Endres R, Grey H: Antigen recognition by T cells and B cells: recognition of cross-reactivity between native and denatured forms of globular antigens. Clin Immunol Immunopathol 13:397–408, 1980Google Scholar
  34. 34.
    Allen PM, Unanue ER: Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas. J Immunol 132:1077–1079, 1984Google Scholar

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Ouahid Bakouche
    • 1
  • Lawrence B. Lachman
    • 1
  1. 1.Department of Cell BiologyThe University of Texas M. D. Anderson Cancer CenterHouston

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