International Ophthalmology

, Volume 16, Issue 1, pp 23–26 | Cite as

Relationship between precorneal retention of viscous eye drops and tear fluid composition

  • A. Ludwig
  • N. J. van Haeringen
  • V. M. W. Bodelier
  • M. Van Ooteghem


The influence of viscolysers on the precorneal residence of a fluorescent tracer was determined, using slit lamp fluorophotometry. The solution acceptability was evaluated by the volunteers by answering a standard questionnaire.

The relationship between precorneal retention of viscous eye drops, discomfort and tear fluid composition after instillation of various cellulosic solutions was examined. Irritating hydroxypropylcellulose solution increases the total protein concentration of tears, without change in the ratio of lysozyme to total protein.

Key words

precorneal retention tear fluid composition viscous eye drops 









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  1. 1.
    Blaug SM, Canada AT. Relationship of viscosity, contact time and prolongation of action of methylcellulose containing ophthalmic solutions. Am J Hosp Pharm 1965; 22: 662–6.Google Scholar
  2. 2.
    Hardberger R, Hanna C, Boyd CM. Effects of drug vehicles on ocular contact time. Arch Ophthalmol 1975; 93: 42–5.Google Scholar
  3. 3.
    Trueblood JH, Rossomondo RM, Carlton WH, Wilson LA. Corneal contact times of ophthalmic vehicles. Arch Ophthalmol 1975; 93: 127–30.Google Scholar
  4. 4.
    Ludwig A, Van Ooteghem M. The study of the precorneal dynamics of ophthalmic solutions by fluorophotometry. Pharm Acta Helv 1986; 85: 59–65.Google Scholar
  5. 5.
    Bradford MM. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–53.Google Scholar
  6. 6.
    Ensink FTE, van Haeringen NJ. Pitfalls in the assay of lysozyme in human tear fluid. Ophthalmic Res 1977; 9: 366–73.Google Scholar
  7. 7.
    Tiffany JM, Winter N, Bliss G. Tear film stability and tear surface tension. Curr Eye Res 1989; 8: 507–15.Google Scholar
  8. 8.
    Ludwig A, Van Ooteghem M. The evaluation of viscous ophthalmic vehicles by slit lamp fluorophotometry in humans. Int J Pharmaceutics 1989; 54: 95–102.Google Scholar
  9. 9.
    Ludwig A, Van Ooteghem M. Influence of the surface tension of eye drops on the retention of a tracer in the precorneal area of human eyes. J Pharm Belg 1988; 43: 157–62.Google Scholar

Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • A. Ludwig
    • 1
  • N. J. van Haeringen
    • 2
  • V. M. W. Bodelier
    • 2
  • M. Van Ooteghem
    • 1
  1. 1.University of Antwerp (UIA)Belgium
  2. 2.The Netherlands Ophthalmic Research InstituteAmsterdamThe Netherlands

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