Skip to main content

Human T-lymphotropic retroviruses in adult T-cell leukemia-lymphoma and acquired immune deficiency syndrome

This is a preview of subscription content, access via your institution.

References

  1. Wong-Staal F, Gallo RC: The transforming genes of primate and other retroviruses and their human homologs.In Viral Oncology, G Klein (ed). New York, Raven Press, 1982, pp 153–171

    Google Scholar 

  2. Jarrett W, Crawford EM, Martin MB, Davie F: Leukemia in the cat. Transmission experiments with leukaemia (lymphosarcoma). Nature 202:567–570, 1964

    Google Scholar 

  3. Hardy WD, Zuckerman AJ, McClelland HW, Snyder HW, Essex M, Francis D: Immunology and epidemiology of feline leukemia virus nonproducer lymphomas.In Viruses in Naturally Occurring Cancers, M Essex, G Todaro, H zur Hausen (ed). New York, Cold Spring Harbor Press, 1980, pp 677–699

    Google Scholar 

  4. Rokjo JL, Hoover EA, Quackenbush SL, Olsen RG: Reactivation of latent leukemia virus infection. Nature 298:385–388, 1982

    Google Scholar 

  5. Burny A, Bruck C, Chantrenne H, Cleuter Y, Dekegel D, Ghysdael J, Kettmann R, Leclerg M, Leunen J, Mammericks M, Portetelle D: Bovine leukemia virus: molecular biology and epidemiology.In Viral Oncology, G Klein (ed). New York, Raven Press, 1980, pp 231–289

    Google Scholar 

  6. Martin MA, Bryan T, Rasheed S, Khan AS: Identification and cloning of endogenous retroviral sequences present in human DNA. Proc Natl Acad Sci USA 78:4892–4896, 1981

    Google Scholar 

  7. Bonner RA, O'Connel CO, Cohen M: Cloned endogenous retroviral sequences from human DNA. Proc Natl Acad Sci USA 80:4709–4713, 1982

    Google Scholar 

  8. Bishop MJ: Retroviruses. Annu Rev Biochem 47:35–88, 1978

    Google Scholar 

  9. Duesberg PH: Transforming genes of retroviruses. Cold Spring Harbor Symp Quant Biol 44:13–30, 1979

    Google Scholar 

  10. Hayward WS, Neel BG, Astrin SM: Induction of lymphoid leukosis by avian leukosis virus: Activation of a cellular “onc” gene by promotor insertion. Nature 290:475–480, 1981

    Google Scholar 

  11. Morgan DA, Ruscetti FW, Gallo RC: Selectivein vitro growth of T-lymphocytes from normal human bone marrow. Science 193:1007–1008, 1976

    Google Scholar 

  12. Sarin PS, Gallo RC: Human T-cell growth factor. CRC Crit Rev Immunol 4:279–305, 1984

    Google Scholar 

  13. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JA, Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77:7415–7419, 1980

    Google Scholar 

  14. Poiesz BJ, Ruscetti FW, Reitz MS, Kalyanaraman VS, Gallo RC: Isolation of a new type-C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia. Nature 294:268–271, 1981

    Google Scholar 

  15. Takatsuki K, Uchiyama T, Ueshima Y, Hattori T: Adult T-cell leukemia: Further clinical observations and cytogenetic and functional studies of leukemic cells. Jap J Clin Oncol 9:317–324, 1979

    Google Scholar 

  16. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H: Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood 50:481–492, 1977

    Google Scholar 

  17. Catovsky D, Greaves MF, Rose M, Galton DAG, Goolden AWG, McCluskey DR, White JM, Lampert I, Bourikas G, Ireland R, Brownell AI, Bridges JM, Blattner WA, Gallo RC: Adult T-cell lymphoma-leukaemia in blacks from the West Indies. Lancet 1:639–642, 1982

    Google Scholar 

  18. Rho HM, Poiesz B, Ruscetti FW, Gallo RC: Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology 112:355–360, 1981

    Google Scholar 

  19. Sarin PS, Gallo RC: Human T-cell leukemia-lymphoma virus (HTLV).In Progress in Hematology, EB Brown (ed). New York, Grune and Stratton, 1983, pp 149–161

    Google Scholar 

  20. Reitz MS, Poiesz BJ, Ruscetti FW, Gallo RC: Characterization and distribution of nucleic acid sequences of a novel type-C retrovirus isolated from neoplastic human T-lymphocytes. Proc Natl Acad Sci USA 78:1887–1891, 1981

    Google Scholar 

  21. Kalyanaraman VS, Sarngadharan MG, Poiesz BJ, Ruscetti FW, Gallo RC: Immunological properties of a type-C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses. J Virol 81:906–915, 1981

    Google Scholar 

  22. Robert-Guroff M, Ruscetti FW, Posner LE, Poiesz BJ, Gallo RC: Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody. J Exp Med 154:1957–1964, 1981

    Google Scholar 

  23. Popovic M, Sarin PS, Robert-Guroff M, Kalyanaraman VS, Mann D, Minowada J, Gallo RC: Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 219:856–859, 1983

    Google Scholar 

  24. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y: Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukemic T-cells. Nature 294:770–771, 1981

    Google Scholar 

  25. Yoshida M, Miyoshi I, Hinuma Y: Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79:2031–2035, 1982

    Google Scholar 

  26. Haynes BF, Miller SE, Moore TO, Dunn PH, Bolognesi DP, Metzgar RS: Identification of human T-cell leukemia virus in a Japanese patient with adult cell leukemia and cutaneous lymphomatous vasculities. Proc Natl Acad Sci USA 80:2054–2058, 1983

    Google Scholar 

  27. Vyth-Drees FA, de Vries JE: Human T-cell leukemia virus in lymphocytes from a T-cell leukaemia patient originating from Surinam. Lancet 2:993, 1983

    Google Scholar 

  28. Sarin PS, Aoki T, Shibata A, Ohnishi Y, Aoyagi Y, Miyakoshi H, Emura I, Kalyanaraman VS, Robert-Guroff M, Popovic M, Sarngadharan M, Nowell PC, Gallo RC: High incidence of human type-C retrovirus (HTLV) in family members of a HTLV-positive Japanese T-cell leukemia patient. Proc Natl Acad Sci USA 80:2370–2374, 1983

    Google Scholar 

  29. Kalyanaraman VS, Sarngadharan MG, Robert-Guroff M, Miyoshi I, Blayney D, Golde D, Gallo RC: A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of Hairy cell leukemia. Science 218:571–573, 1982

    Google Scholar 

  30. Golde DW, Quan S, Cline MJ: Human T-lymphocyte cell line producing colony stimulating factor. Blood 52:1068–1072, 1978

    Google Scholar 

  31. Reitz MS Jr, Popovic M, Haynes BF, Clark SC, Gallo RC: Relatedness by nucleic acid hybridization of new isolates of human T-cell leukemia-lymphoma virus (HTLV) and demonstration of provirus in uncultured leukemic blood cells. Virology 126:688–692, 1983

    Google Scholar 

  32. Nagy K, Clapham P, Cheingsong-Popov R, Weiss RA: Human T cell leukemia virus type 1, Induction of syncytia and inhibition by patient's sera. Int J Cancer 32:321–328, 1983

    Google Scholar 

  33. Nagy K, Weiss RA, Clapham P, Cheinsong-Popov R: Human T cell leukemia-lymphoma virus envelope antigens. In Human T cell Leukemia-Lymphoma Viruses. RC Gallo, M Essex, L Gross (eds). New York, Cold Spring Harbor Press, 1984, pp 121–123

    Google Scholar 

  34. Popovic M, Reitz MS Jr, Sarngadharan MG, Robert-Guroff M, Kalyanaraman VS, Nakao Y, Miyoshi I, Minowada J, Yoshida M, Ito Y, Gallo RC: The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group. Nature 300:63–66, 1982

    Google Scholar 

  35. Seiki M, Hattori S, Hirayama Y, Yoshida M: Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA 80:3618–3622, 1983

    Google Scholar 

  36. Schupbach J, Kalyanaraman VS, Sarngadharan MG, Blattner WA, Gallo RC: Antibodies against three purified proteins of the human type C retrovirus, human T-cell leukemia-lymphoma virus, in adult T-cell leukemia-lymphoma patients and healthy Blacks from the Caribbean. Cancer Res 43:886–891, 1983

    Google Scholar 

  37. Oroszlan S, Sarngadharan MG, Copeland TD, Kalyanaraman VS, Gilden RV, Gallo RC: Primary structure analysis of the major internal protein p24 of human type C T-cell leukemia virus. Proc Natl Acad Sci USA 79:1291–1294, 1982

    Google Scholar 

  38. Copeland TD, Oroszlan S, Kalyanaraman VS, Sarngadharan MG, Gallo RC: Complete amino acid sequence of human T-cell leukemia virus structural protein p15. FEBS 162:390–395, 1983

    Google Scholar 

  39. Robert-Guroff M, Schupbach J, Blayney DW, Kalyanaraman VS, Merino F, Lanier A, Sarngadharan MG, Clark J, Saxinger WC, Blattner WA, Gallo RC: Seroepidemiologic studies on HTLV-1.In Human T-cell Leukemia-Lymphoma Viruses, RC Gallo, M Essex, L Gross (eds). New York, Cold Spring Harbor Press, 1984, pp 285–295

    Google Scholar 

  40. Blattner WA, Kalyanaraman VS, Robert-Guroff M, Lister TA, Galton DAG, Sarin PS, Crawford MH, Catovsky D, Greaves M, Gallo RC: The human type-C retrovirus, HTLV, in Blacks from the Caribbean region, and relationship to adult T-cell leukemia/lymphoma. Int J Cancer 30:257–264, 1982

    Google Scholar 

  41. Gallo RC, Kalyanaraman VS, Sarngadharan MG, Sliski A, Vonderheid EC, Maeda M, Nakao Y, Yamada K, Ito Y, Gutensohn N, Murphy S, Bunn PA Jr, Catovsky D, Greaves MF, Blayney DW, Blattner W, Jarrett WFH, Jegasothy BV, Jaffe E, Cossman J, Broder S, Fisher RI, Golde DW, Robert-Guroff M: Association of the human type C retrovirus with a subset of adult T-cell cancers. Cancer Res 43:3892–3899, 1983

    Google Scholar 

  42. Robert-Guroff M, Nakao Y, Notake K, Ito Y, Sliski A, Gallo RC: Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia. Science 215:975–978, 1982

    Google Scholar 

  43. Hinuma Y, Komoda H, Chosa T, Kondo T, Kohakura M, Takenaka T, Kiksechi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takiuchi Y, Uchino H, Hanaoka M: Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: A nation-wide seroepidemiologic study. Int J Cancer 29:631–635, 1982

    Google Scholar 

  44. Robert-Guroff M, Kalyanaraman VS, Blattner WA, Popovic M, Sarngadharan MG, Maeda M, Blayney D, Catovsky D, Bunn PA, Shibata A, Nakao Y, Ito Y, Aoki T, Gallo RC: Evidence for human T cell lymphoma-leukemia virus infection of family members of human T cell lymphoma-leukemia virus positive T cell leukemia-lymphoma patients. J Exp Med 157:248–258, 1983

    Google Scholar 

  45. Miyoshi I, Yoshimoto S, Fujishita M, Hirokuni T, Kubonishi I, Niiya K, Minezawa M: Natural adult T-cell leukemia virus infection in Japanese monkeys. Lancet 2:658–659, 1982

    Google Scholar 

  46. Popovic M, Lange-Wantzin G, Sarin PS, Mann D, Gallo RC: Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc Natl Acad Sci USA 80:5402–5406, 1983

    Google Scholar 

  47. Markham PD, Salahuddin SZ, Kalyanaraman VS, Popovic M, Sarin P, Gallo RC: Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T-cell leukemia-lymphoma virus (HTLV). Int J Cancer 31:413–420, 1983

    Google Scholar 

  48. Ruscetti FW, Robert-Guroff M, Ceccherini-Nelli L, Minoda J, Popovic M, Gallo RC: Persistentin vitro infection by human T-cell leukemia-lymphoma virus (HTLV) of normal human T-lymphocytes from blood relatives of patients with HTLV associated mature T-cell neoplasms. Int J Cancer 31:171–180, 1983

    Google Scholar 

  49. Markham PD, Salahuddin SZ, Macchi B, Robert-Guroff M, Gallo RC: Transformation of different phenotypic types of human bone marrow T-lymphocytes by HTLV-1. Int J Cancer 33:13–17, 1984

    Google Scholar 

  50. Gallo RC, Mann D, Broder S, Ruscetti FW, Maeda M, Kalyanaraman VS, Robert-Guroff M, Reitz MS Jr: Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 79:5680–5683, 1982

    Google Scholar 

  51. Gallo RC, Wong-Staal F, Sarin PS: Cellularonc genes, T-cell leukaemia-lymphoma virus, and leukaemias and lymphomas of man.In Mechanisms of Viral Leukaemogenesis, JM Goldman, JO Jarrett (eds). London, Churchill Living-stone, 1984, pp 11–37

    Google Scholar 

  52. Mann DL, Popovic M, Sarin P, Murray C, Reitz MS, Strong DM, Haynes BF, Gallo RC, Blattner WA: Cell lines producing human T-cell lymphoma virus show altered PHA expression. Nature 305:58–60, 1983

    Google Scholar 

  53. Miyoshi I, Taguchi H, Fujishita M, Yoshimoto S, Kubonishi I, Ohtsuki Y, Shiraishi Y, Akagi T: Transformation of monkey lymphocytes with adult T-cell leukemia virus. Lancet 1:1016, 1982

    Google Scholar 

  54. Miyoshi I, Yoshimoto S, Taguchi H, Kubonishi I, Fujishita M, Ohtsuki Y, Shiraishi Y: Transformation of rabbit lymphocytes with T-cell leukemia virus. Gann 74:1–14, 1983

    Google Scholar 

  55. Salahuddin SZ, Markham PD, Lindner SG, Gootenberg J, Popovic M, Hemmi H, Sarin PS, Gallo RC: Lymphokine production by cultured human T-cells transformed by human T-cell leukemia-lymphoma virus-1. Science 223:703–707, 1984

    Google Scholar 

  56. Clark SC, Arya SK, Wong-Staal F, Matsumoto-Kobayashi M, Kay RM, Kaufman RJ, Brown EL, Shoemaker C, Copeland T, Oroszlan S, Smith K, Sarngadharan MG, Lindner SG, Gallo RC: Human T-cell growth factor: Partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells. Proc Natl Acad Sci USA 81:2543–2547, 1984

    Google Scholar 

  57. Doolittle RF, Hunkapillar MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Antoniades HN: Simian sarcoma virusonc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221:275–277, 1983

    Google Scholar 

  58. Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnson A, Wasteson A, Westermark B, Heldin CH, Huang JS, Deul TF: Platelet derived growth factor is structurally related to the putative transforming protein p24 of simian sarcoma virus. Nature 304:35–39, 1983

    Google Scholar 

  59. Sarin PS, Gallo RC: Role of viruses in the etiology of acquired immune deficiency syndrome.In Basics of AIDS, P Ebbesen, R Biggar, M Melbye (eds). Copenhagen, Munksgaard, 1984 (in press)

    Google Scholar 

  60. Gallo RC, Sarin PS, Gelmann EP, Robert-Guroff M, Richardson E, Kalyanaraman VS, Mann D, Sidhu GD, Stahl RE, Zolla-Pazner S, Leibowitch J, Popovic M: Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 220:865–867, 1983

    Google Scholar 

  61. Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker TJ, Redfield R, Oleske J, Safai B, White G, Foster P, Markham PD: Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224:500–503, 1984

    Google Scholar 

  62. Popovic M, Sarngadharan MG, Read E, Gallo RC: Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224:497–500, 1984

    Google Scholar 

  63. Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauget C, Axler-Blim C, Vezinet-Brun F, Rouzious C, Rozenbaum W, Montagnier L: Isolation of a T-lymphotropic retrovirus from a patient at risk for AIDS. Science 220:868–871, 1983

    Google Scholar 

  64. Sarngadharan MG, Popovic M, Bruch L, Schupbach J, Gallo RC: Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science 224:506–508, 1984

    Google Scholar 

  65. Schupbach J, Popovic M, Gilden RV, Gonda MA, Sarngadharan MG, Gallo RC: Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS. Science 224:503–505, 1984

    Google Scholar 

  66. Essex M, McLane MF, Lee TH, Falk L, Howe CWS, Mullins JI, Cabradilla C, Francis DP: Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science 220:859–862, 1983

    Google Scholar 

  67. Essex ME, McLane MF, Tachibana N, Francis DP, Lee TH: Seroepidemiology of human T-cell leukemia virus in relation to immunosuppression and the acquired immunodeficiency syndrome.In Human T-Cell Leukemia-Lymphoma Viruses, RC Gallo, M Essex, L Gross (eds). New York, Cold Spring Harbor Press, 1984, pp 355–362

    Google Scholar 

  68. Gelmann EP, Popovic M, Blayney D, Masur H, Sidhu G, Stahl RE, Gallo RC: Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS. Science 220:862–865, 1983

    Google Scholar 

  69. Popovic M, Kalyanaraman VS, Mann DL, Richardson E, Sarin PS, Gallo RC: Infection and transformation of T cells by human T cell leukemia/lymphoma virus of subgroups I and II (HTLV-I, HTLV-II).In Human T-Cell Leukemia-Lymphoma Viruses, RC Gallo, M Essex, L Gross (eds). New York, Cold Spring Harbor Press, 1984, pp 217–227

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sarin, P.S., Gallo, R.C. Human T-lymphotropic retroviruses in adult T-cell leukemia-lymphoma and acquired immune deficiency syndrome. J Clin Immunol 4, 415–423 (1984). https://doi.org/10.1007/BF00916570

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00916570

Key words

  • Adult T-cell leukemia-lymphoma
  • acquired immune deficiency syndrome (AIDS)
  • human T-lymphotropic virus (HTLV)
  • retroviruses
  • T-cell malignancies