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Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors

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Abstract

A variety of steroidal and nonsteroidal antiinflammatory agents (NSAs) were compared for their effectiveness against a developing acute inflammatory reaction. Only BW 755C [3-amino-l-(m-trifiuoromethyl)-phenyI-2-pyrazole] was immediately effective when administered 2 h after carrageenin, as the 3-h swelling was significantly reduced. Dexamethasone, a steroidal antiinflammatory agent, produced a delayed reduction. When administered at 2 h postcarrageenin, there was no effect at 3 h; but at 6 h, dexamethasone significantly reduced the swelling. In contrast, neither of the classic NSAs, aspirin or indomethacin, were effective when administered after the carrageenin. The results demonstrating a postcarrageenin effectiveness by BW 755C and dexamethasone are discussed as a possible reflection of an action on the lipoxygenase pathways of the arachidonic cascade that is not shared by the classic NSA.

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Author notes

  1. Michael P. Holsapple

    Present address: Department of Microbiology and Immunology, Virginia Commonwealth University, MCV Station, P.O. Box 678, 23298, Richmond, Virginia

Authors and Affiliations

  1. School of Pharmacy and Pharmacal Sciences Department of Pharmacology and Toxicology, Purdue University, 47907, West Lafayette, Indiana

    Michael P. Holsapple & George K. W. Yim

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  1. Michael P. Holsapple
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  2. George K. W. Yim
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Holsapple, M.P., Yim, G.K.W. Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors. Inflammation 8, 223–230 (1984). https://doi.org/10.1007/BF00916412

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