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Leukotriene production associated with leukocyte membrane destruction

Evidence of a terminal signal

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Abstract

Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell function and that generation at this stage could constitute a terminal chemotactic signal.

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Authors and Affiliations

  1. Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden

    Floyd A. Green

  2. Department of Rheumatology, Karolinska Sjukhuset, Stockholm, Sweden

    Floyd A. Green

Authors
  1. Floyd A. Green
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Supported by the Swedish Medical Research Council Grant 03X-07135.

On leave from the Division of Rheumatology, Department of Medicine, State University of New York at Buffalo, and the Veterans Administration Medical Center, Buffalo, New York.

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Green, F.A. Leukotriene production associated with leukocyte membrane destruction. Inflammation 12, 133–140 (1988). https://doi.org/10.1007/BF00916396

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