, Volume 7, Issue 4, pp 331–338 | Cite as

Hyperoxia stimulates alveolar macrophages to produce and release a factor which increases neutrophil adherence

  • C. Michael Bowman
  • Ruth N. Harada
  • John E. Repine
Original Articles


Hyperoxia stimulates alveolar macrophages (AM) to make and release a factor which increases neutrophil adherence to nylon fiber. Production of the neutrophil adherence-stimulating factor by AM exposed to hyperoxia is maximal after AM have been exposed to hyperoxia for 72 h and requires protein synthesis by intact AM. The adherence factor is heat-labile and by column chromatography elutes in a molecular-weight range of approximately 8000–18,000 daltons. The AM-derived adherence factor could influence accumulation of neutrophils in the lungs of animals exposed to hyperoxia and contribute to neutrophil-mediated lung injury from hyperoxia.


Public Health Internal Medicine Protein Synthesis Nylon Column Chromatography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • C. Michael Bowman
    • 1
  • Ruth N. Harada
    • 1
  • John E. Repine
    • 1
  1. 1.Webb-Waring Lung Institute and Departments of Pediatrics and MedicineSchool of Medicine University of Colorado Health Sciences CenterDenver

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