Inflammation

, Volume 7, Issue 4, pp 331–338 | Cite as

Hyperoxia stimulates alveolar macrophages to produce and release a factor which increases neutrophil adherence

  • C. Michael Bowman
  • Ruth N. Harada
  • John E. Repine
Original Articles

Abstract

Hyperoxia stimulates alveolar macrophages (AM) to make and release a factor which increases neutrophil adherence to nylon fiber. Production of the neutrophil adherence-stimulating factor by AM exposed to hyperoxia is maximal after AM have been exposed to hyperoxia for 72 h and requires protein synthesis by intact AM. The adherence factor is heat-labile and by column chromatography elutes in a molecular-weight range of approximately 8000–18,000 daltons. The AM-derived adherence factor could influence accumulation of neutrophils in the lungs of animals exposed to hyperoxia and contribute to neutrophil-mediated lung injury from hyperoxia.

Keywords

Public Health Internal Medicine Protein Synthesis Nylon Column Chromatography 

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • C. Michael Bowman
    • 1
  • Ruth N. Harada
    • 1
  • John E. Repine
    • 1
  1. 1.Webb-Waring Lung Institute and Departments of Pediatrics and MedicineSchool of Medicine University of Colorado Health Sciences CenterDenver

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