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Stereotypic responses to infection and inflammation

Probable activation of phagocytic cells

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Abstract

There is a sequence of Stereotypie metabolic changes in rats subjected to inflammation or infection. In each stress, rats respond with increases in body temperature and plasma insulin and with decreases in plasma zinc, ketone bodies, and free fatty acids. The data suggest that infection or inflammation causes an activation of phagocytic cells and also that leukocytic endogenous mediator, when injected into rats, causes some of the same alterations. Rats doubly vagotomized respond to infection in the same fashion as intact rats.

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Authors and Affiliations

  1. United States Army Medical Research Institute of Infectious Diseases Fort Detrick, 21701, Frederick, Maryland

    Harold A. Neufeld & Judith G. Pace

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  1. Harold A. Neufeld
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  2. Judith G. Pace
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Additional information

In conducting the research described in this report, the investigators adhered to the “Guide for the Care and Use of Laboratory Animals,” as promulgated by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council. The facilities are fully accredited by the American Association for Accreditation of Laboratory Animal Care.

The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense.

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Neufeld, H.A., Pace, J.G. Stereotypic responses to infection and inflammation. Inflammation 6, 137–146 (1982). https://doi.org/10.1007/BF00916238

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