Inflammation

, Volume 8, Issue 2, pp 171–179 | Cite as

Distribution of α2-macroglobulin in normal, inflammatory, and tumor tissues in rats

  • Hideo Okubo
  • Hiromi Ishibashi
  • Katsunori Shibata
  • Kazunori Tsuda-Kawamura
  • Toshiyuki Yanase
Original Articles

Abstract

Distribution of uptake and catabolism of intravenously administered125l-labeled rat α2-macroglobulin(125I-α2MG) were examined in normal, inflammatory, and tumor tissues of rats. Clearance of intravenously administered [125l]α2MG from the circulation was rapid. Accumulation of this compound into inflammatory tissue was 2–3 times more extensive than in normal tissues. The accumulation into sarcoma tissue was much less. Radioactivity in TCA-PTA precipitates remained fairly constant for the first 12 h in inflammatory tissue and for the first 24 h in sarcoma. These patterns of accumulation were never observed in the normal tissues. As the kidney preferentially accumulated large amounts of [125l]α2MG in the nondegraded form and its degradation products, the tissue may play a special role in the metabolism of α2MG. Rapid clearance from the circulation and relatively small amounts of accumulation in tissues suggest that α2MG may function as a protease inhibitor, mainly in the circulation rather than in the tissues.

Keywords

Public Health Internal Medicine Sarcoma Tumor Tissue Protease Inhibitor 

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Hideo Okubo
    • 1
  • Hiromi Ishibashi
    • 1
  • Katsunori Shibata
    • 1
  • Kazunori Tsuda-Kawamura
    • 2
  • Toshiyuki Yanase
    • 1
  1. 1.First Department of Medicine, Faculty of MedicineKyushu UniversityFukuokaJapan
  2. 2.Second Department of MedicineMiyazaki Medical CollegeMiyazakiJapan

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