Journal of Clinical Immunology

, Volume 2, Issue 1, pp 55–58 | Cite as

Pancytopenia with mixed cryoglobulinemia: Evidence for anti-precursor cell activity of cryoglobulin—Effects of plasmapheresis

  • Perri A. Ginder
  • Donald F. Middendorf
  • Nabih I. Abdou
Short Communication


The efficacy of plasmapheresis in a patient with mixed cryoglobulinemia and pancytopenia is shown. The cryoglobulin was shown to have precursor cell suppressing activity and its depletion by plasmapheresis resulted in improvement of blood counts. Indications, limitations and guidelines for plasmapheresis in various diseases are discussed.

Key words

Cryoglobulinemia plasmapheresis pancytopenia colony-forming unit in culture (CFU-C) 


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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Perri A. Ginder
    • 1
    • 2
  • Donald F. Middendorf
    • 1
    • 2
  • Nabih I. Abdou
    • 1
    • 2
  1. 1.Department of Medicine, Division of Allergy, Clinical Immunology and RheumatologyUniversity of Kansas Medical CenterKansas City
  2. 2.Kansas City Veterans Administration Medical CenterKansas City

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